Study of TYK-00540 Tablets in Patients With Advanced Solid Tumors

This study is testing a new tablet medication called TYK-00540 in patients with advanced solid tumors (cancers that form masses in the body). The study is evaluating safety, dosing, and effectiveness across several cancer types, including ovarian cancer, breast cancer, and others. **You may be eligible if...** - You are 18 years or older - You have a confirmed advanced or metastatic solid tumor with no remaining standard treatment options, or you have refused standard treatment - For specific cohorts: certain cancer types may be required (such as platinum-resistant ovarian cancer or specific breast cancer subtypes) - You are in relatively good physical condition (ECOG score 0-1) **You may NOT be eligible if...** - You have already received certain prior treatments that overlap with this drug's mechanism - You have significant heart, liver, or kidney problems - You are pregnant or breastfeeding - You have brain metastases that are not stable Talk to your doctor to see if this trial is right for you.