RecruitingNot ApplicableNCT06952153

Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment

Comparison of Phaco Surgery and Goniosynechialysis Versus Trabeculectomy Outcomes in Glaucoma Patients


Sponsor

University of Medicine and Pharmacy at Ho Chi Minh City

Enrollment

82 participants

Start Date

Jun 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma. The main questions it aims to answer are: * Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy? * What are the rates of postoperative complications or adverse events between the two surgical approaches? * How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications? Researchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma. Participants will: Be randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two surgical options for patients with a type of glaucoma (angle-closure glaucoma with peripheral anterior synechiae) who also have cataracts. One option is cataract surgery combined with a procedure to open the drainage angle of the eye (goniosynechialysis); the other is a traditional glaucoma surgery called trabeculectomy. The goal is to find out which approach better lowers eye pressure while preserving vision. **You may be eligible if...** - You are 40 years or older - You have glaucoma with abnormal scarring in the drainage angle of the eye (PAS affecting more than 180 degrees) - Your eye pressure is above 21 mmHg despite taking glaucoma medications - You have a cataract affecting your vision (grade 1 to 3) - You have documented vision loss from glaucoma **You may NOT be eligible if...** - Your glaucoma is very advanced (limited to only light perception vision) - You have a secondary cause for your angle-closure glaucoma - You have had prior eye surgery or laser iridotomy - You have severe corneal disease or use chronic corticosteroids - Your cataract is very advanced (grade 4 or 5) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREPhacoemulsification with Goniosynechialysis

This procedure involves standard phacoemulsification cataract surgery combined with goniosynechialysis, which mechanically separates peripheral anterior synechiae to open the anterior chamber angle. It aims to both remove the cataractous lens and restore aqueous outflow in patients with primary angle-closure glaucoma.

PROCEDURETrabeculectomy with 5FU

Trabeculectomy is a glaucoma filtration procedure designed to lower intraocular pressure by creating a new drainage pathway from the anterior chamber to the sub-conjunctival space. It is considered the standard surgical intervention for medically uncontrolled glaucoma.


Locations(1)

HCMC University of Medicine and Pharmacy

Ho Chi Minh City, Vietnam

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NCT06952153


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