RecruitingNCT06952400

The Registry Study of Genetic Alterations of Melanoma in Taiwan

T1622 The Registry Study of Genetic Alterations of Melanoma in Taiwan

Sponsor

National Health Research Institutes, Taiwan

Enrollment

250 participants

Start Date

Aug 22, 2022

Study Type

OBSERVATIONAL

Conditions

Primary Melanoma of the Extremity

Summary

Cutaneous melanoma is the most aggressive malignancy in skin cancers. Cutaneous melanoma is a rare disease in Taiwan with an incidence rate of around 1/100,000. Acral lentiginous melanoma is the most common subtype and comprises more than half of cutaneous melanoma in Asia including Taiwan but only 1% in Caucasians. In addition, mucosal melanoma accounts for more than 20% of malignancy melanoma in Taiwan but only 1% in Caucasians. Acral and mucosal melanomas have distinct epidemiological, clinical, pathological and genetic features from non-acral melanoma which is commonly seen in Western countries. Comparing with melanoma in Caucasians, Asian melanoma has higher recurrence rate after primary surgery, lower response rate to immunotherapy, and shorter progression-free survival for immunotherapy and targeted therapy leading generally poor survival outcomes regardless stage.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is creating a registry to better understand the genetic features of melanoma (skin cancer) in patients in Taiwan. By collecting tumor tissue and genetic data, researchers aim to identify patterns that could improve targeted treatment options for different stages of melanoma, from early to advanced disease. **You may be eligible if...** - You are over 18 years old - You have a confirmed diagnosis of melanoma at any stage (early, locally advanced, or metastatic) - You are willing to provide a tumor tissue sample for genetic analysis - You have a life expectancy of more than 3 months and are willing to attend regular follow-up visits - Your general health allows participation (ECOG performance status below 3) **You may NOT be eligible if...** - You are unable to provide a complete medical history - No tumor tissue is available for genetic testing - You are unwilling to undergo regular follow-up Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(16)

Taipei Veterans General Hospital

Taipei, Taiwan/Taipei, Taiwan

CHANG GUNG MEMORIAL HOSPITAL, Chiayi

Chiayi City, Taiwan

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

Kaohsiung Medical University

Kaohsiung City, Taiwan

National Taiwan University Hospital ,NTUH Hsin-Chu Branch

Sindian City, Taiwan

China Medical University Hospital

Taichung, Taiwan

Chung Shan Medical University Hospital

Taichung, Taiwan

Taichung Veterans General Hospital

Taichung, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, Taiwan

MacKay Memorial Hospital

Taipei, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Medical University -Ministry of Health and Welfare Shuang-Ho Hospital

Taipei, Taiwan

Wan Fang Hospital, Taipei Medical University

Taipei, Taiwan

CHANG GUNG MEMORIAL HOSPITAL, Linkou

Taoyuan, Taiwan

Taoyuan General Hospital, Ministry of Health and Welfare

Taoyuan, Taiwan

View Full Details on ClinicalTrials.gov

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NCT06952400