Resilience Among Individuals With Opioid Use Disorder
A Novel Human Laboratory Model of Resilience Among Individuals With Opioid Use Disorder
Johns Hopkins University
125 participants
May 29, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.
Eligibility
Inclusion Criteria5
- Can provide informed consent and can comply with study procedures
- Adults aged ≥18 years
- Meet Diagnostic and Statistical Manual (DSM-5) criteria for current opioid use disorder or are currently receiving pharmacotherapy for the treatment of OUD (e.g. methadone or buprenorphine maintenance treatment \[remission\])
- Urine sample that tests positive for opioids
- Test negative for pregnancy at screening (females only)
Exclusion Criteria2
- Being pregnant or breastfeeding
- Significant mental health or physical disorder, or life circumstances, that is judged by the investigators to interfere with study participation
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Interventions
This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.
In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06954402