Personalized Tumor Neoantigen mRNA Therapy for Advanced Intrahepatic Cholangiocarcinoma

This study is testing a personalized cancer vaccine approach for people with advanced bile duct cancer inside the liver (intrahepatic cholangiocarcinoma). Researchers analyze a patient's tumor to identify unique mutation targets, then create a custom mRNA vaccine designed to train the immune system to attack those specific cancer cells. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with unresectable (cannot be surgically removed) advanced bile duct cancer inside the liver - You have not yet received any systemic treatment for this cancer - Your cancer has at least one measurable lesion - Your heart, liver, kidneys, and blood counts are within acceptable ranges - You are in reasonably good overall health **You may NOT be eligible if...** - Your cancer has spread to areas outside the liver that prevent a safe biopsy - You have already received chemotherapy or other systemic treatments for this cancer - You have active autoimmune disease or are on immune-suppressing medications - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.