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RecruitingPhase 2Phase 3NCT06956950

Magnesium Sulfate in Addition to Bupivacaine in Ultrasound-guided Transmuscular Quadratus Lumborum Block for Post-Operative Analgesia After Total Hip Arthroplasty

Efficacy of Adding Magnesium Sulfate to Bupivacaine in Ultrasound-guided Transmuscular Quadratus Lumborum Block for Postoperative Analgesia in Patients Underdoing Hip Arthroplasty

Sponsor

Tanta University

Enrollment

70 participants

Start Date

May 1, 2025

Study Type

INTERVENTIONAL

Conditions

Pain Score Reduction

Summary

The aim of this clinical trial is to evaluate the efficacy of adding magnesium sulfate to bupivacaine in ultrasound-guided transmuscular quadratus lumborum block for postoperative analgesia in adult patients underdoing hip arthroplasty. The main questions it aims to answer are: * Does Magnesium sulphate lower Pain score (VAS) postoperatively. * Does Magnesium sulphate lowerTotal opioid consumption postoperatively. and What side effects do participants have when taking Magnesium sulphate? Researchers will compare Magnesium sulphate to a placebo (a look-alike substance that contains no drug) to see if Magnesium sulphate works to lower pain score. Participants will: * Take with have ultrasound-guided transmuscular quadratus lumborum block after surgery using bupivacaine with Magnesium sulphate or with placebo * Followed up 48 hours postoperatively to monitor pain score or any reported side effect.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Age ≥ 18 years.
  • American Society of Anesthesiology (ASA) class I-III
  • Undergoing hip arthroplasty .

Exclusion Criteria6

  • Patient refusal.
  • Body mass index (BMI) > 40 Kg/m2.
  • Allergy to local anesthetics or magnesium sulphate.
  • coexisting coagulopathy.
  • Local infection at puncture site.
  • Severe renal impairment ( eGFR < 30 ml/min)

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Interventions

DRUGBupivacaine + Magnesium sulfate

ultrasound-guided transmuscular quadratus lumborum block using 25 ml of 0.25% bupivacaine + 5 ml 10% magnesium sulfate

DRUGBupivacaine + saline

ultrasound-guided transmuscular quadratus lumborum block using 25 ml of 0.25% bupivacaine + 5 ml normal saline

Locations(1)

Faculty of medicine

Tanta, El-Gharbia, Egypt

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NCT06956950