RecruitingNot ApplicableNCT06957405

Remote Mental Practice for Freezing of Gait in Parkinson's Disease

Effects of a Remote Mental and Physical Practice Intervention on Freezing of Gait in People With Parkinson's Disease: a Randomized Controlled Trial

Sponsor

University of Sao Paulo General Hospital

Enrollment

50 participants

Start Date

Jan 25, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease Freezing of Gait

Summary

This single-blind, randomized controlled trial investigates the effects of a remotely delivered intervention based on mental practice (MP) combined with physical practice (PP) on freezing of gait (FOG) severity in people with idiopathic Parkinson's disease (PD). Fifty participants will be randomly assigned to either the experimental group (MP + PP) or a control group (PP + stretching). The intervention consists of 10 video-supervised sessions over 6 weeks. Primary outcomes include the Rapid Turn Test and percentage of time spent with FOG (%FOG). Secondary outcomes include the New Freezing of Gait Questionnaire (NFOG-Q), Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Parkinson's Disease Questionnaire-39 (PDQ-39), and Telephone Montreal Cognitive Assessment (T-MoCA). The study aims to demonstrate whether MP using Dynamic Neuro-Cognitive Imagery (DNI) techniques can effectively reduce FOG severity and improve motor and cognitive function in people with PD.

Eligibility

Inclusion Criteria6

Clinical diagnosis of idiopathic PD;
Use of dopaminergic medication;
Experiencing FOG (positive response to the first question of the New Freezing of Gait Questionnaire - NFOG-Q);
Able to walk independently at home;
Access to internet and video call device;
Agree to participate in the study.

Exclusion Criteria5

Other neurological disorders;
Severe cardiovascular and/or respiratory alterations;
Uncorrected visual and/or auditory alterations;
Cognitive impairment, detectable through the Telephone Montreal Cognitive Assessment (T-MoCA, \< 12);
Inability to perform motor imageryT during the administration of the Kinesthetic and Visual Imagery Questionnaire - 20 (KVIQ-20, \< 20)

Interventions

BEHAVIORALMPPG (Mental and Physical Practice Group)

Participants in this group will undergo 10 remote sessions over 6 weeks, each session lasting 45-60 minutes. Each session consists of: (1) two blocks of first-person kinesthetic MP, conducted while seated with eyes closed and guided using DNI principles; and (2) two blocks of corresponding PP, involving simulated gait components such as ankle mobility, postural weight shifts, and short-distance walking under real-time supervision. Each block lasts approximately 10 minutes. The MP emphasizes attentional focus, sensory detail, and task-specific goals. Sessions are conducted synchronously via video call by trained physiotherapists.

BEHAVIORALPPG (Physical Practice Group)

Participants in the control group will receive 10 remote sessions over 6 weeks, each session lasting 45-60 minutes. Each session consists of the same PP as the experimental group but replaces motor imagery with two 10-minute seated stretching block, focusing on the upper limbs and trunk. The PP follows the same structure and duration as in the experimental group. All sessions are delivered remotely via live video by physiotherapists trained in both protocols. Volume, frequency, and interaction levels are matched between groups to ensure equivalence.