A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder

This study is testing a combination pill containing dextromethorphan (commonly found in cough medicine) and bupropion (an antidepressant) for people with major depressive disorder (MDD). This combination works on the brain in a different way than most current antidepressants and may help people who haven't responded well to other treatments. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with major depressive disorder (without psychosis) - Your current depressive episode has lasted at least 4 weeks - Your depression is at least moderately severe based on clinical assessments - You are not currently responding well to your existing antidepressant **You may NOT be eligible if...** - You have a history of bipolar disorder, schizophrenia, or psychosis - You have active thoughts of suicide with a plan - You have a history of seizures or eating disorders (anorexia/bulimia) - You are pregnant or breastfeeding - You are currently taking certain medications that interact with these drugs Talk to your doctor to see if this trial is right for you.