RecruitingPhase 3NCT06960213

STOP-HAE: A Phase 3 Study of ADX-324 in HAE

STOP-HAE: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of siRNA Targeting of Prekallikrein With ADX-324 in Participants With Hereditary Angioedema


Sponsor

ADARx Pharmaceuticals, Inc.

Enrollment

90 participants

Start Date

Aug 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study will evaluate the efficacy and safety of ADX-324 in participants with Type 1 or Type 2 hereditary angioedema. The study will also evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD), and health-related quality of life measures.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called ADX-324 and a drug called Placebo for people with hae, hereditary angioedema, and other related conditions. The study is currently recruiting participants at 51 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGADX-324

siRNA duplex oligonucleotide

DRUGPlacebo

saline


Locations(51)

ADARx Clinical Site

Litchfield Park, Arizona, United States

ADARx Clinical Site

Little Rock, Arkansas, United States

ADARx Clinical Site

San Diego, California, United States

ADARx Clinical Site

Walnut Creek, California, United States

ADARx Clinical Site

Orlando, Florida, United States

ADARx Clinical Site

Chevy Chase, Maryland, United States

ADARx Clinical Site

Wheaton, Maryland, United States

ADARx Clinical Site

Detroit, Michigan, United States

ADARx Clinical Site

St Louis, Missouri, United States

ADARx Clinical Site

Las Vegas, Nevada, United States

ADARx Clinical Site

New York, New York, United States

ADARx Clinical Site

Cincinnati, Ohio, United States

ADARx Clinical Site

Columbus, Ohio, United States

ADARx Clinical Site

Toledo, Ohio, United States

ADARx Clinical Site

Hershey, Pennsylvania, United States

ADARx Clinical Site

Capital Federal, Buenos Aires, Argentina

ADARx Clinical Site

Buenos Aires, Buenos Aires F.D., Argentina

ADARx Clinical Site

Adelaide, South Australia, Australia

ADARx Clinical Site

Vienna, Austria

ADARx Clinical Site

Edegem, Antwerpen, Belgium

ADARx Clinical Site

Sofia, Bulgaria

ADARx Clinical Site

Edmonton, Alberta, Canada

ADARx Clinical Site

Ottawa, Ontario, Canada

ADARx Clinical Site

Montreal, Quebec, Canada

ADARx Clinical Site

Beijing, China

ADARx Clinical Site

Harbin, China

ADARx Clinical Site

Zhengzhou, China

ADARx Clinical Site

Split, Croatia

ADARx Clinical Site

Zagreb, Croatia

ADARx Clinical Site

Hradec Králové, Czechia

ADARx Clinical Site

Prague, Czechia

ADARx Clinical Site

Nice, Alpes-Maritimes, France

ADARx Clinical Site

Tours, Indre-et-Loire, France

ADARx Clinical Site

Montpellier, France

ADARx Clinical Site

Paris, France

ADARx Clinical Site

Tübingen, Baden-Wurttemberg, Germany

ADARx Clinical Site

Hong Kong, Hong Kong

ADARx Clinical Site

Budapest, Hungary

ADARx Clinical Site

Ramat Gan, Tel Aviv, Israel

ADARx Clinical Site

Ashkelon, Israel

ADARx Clinical Site

Tel Aviv, Israel

ADARx Clinical Site

Krakow, Poland

ADARx Clinical Site

Lodz, Poland

ADARx Clinical Site

Wroclaw, Poland

ADARx Clinical Site

Barcelona, Spain

ADARx Clinical Site

Madrid, Spain

ADARx Clinical Site

Taichung, Taiwan

ADARx Clinical Site

Cambridge, United Kingdom

ADARx Clinical Site

Cardiff, United Kingdom

ADARx Clinical Site

London, United Kingdom

ADARx Clinical Site

Southampton, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT06960213


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