RecruitingPhase 2NCT06961084

Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer

Comparison of I-124 PET/CT to I-123 Whole Body Imaging for the Diagnosis of Thyroid

Sponsor

Thomas Hope

Enrollment

62 participants

Start Date

Dec 4, 2025

Study Type

INTERVENTIONAL

Conditions

Thyroid Cancer

Summary

Persons diagnosed with thyroid cancer are often treated initially with a thyroidectomy, which is followed by ablation using Iodine-131, a therapy which has been shown to be effective and safe. Imaging of metastatic thyroid cancer has been performed with whole body I-131 and Iodine 123 (I-123) imaging for many decades and use I-123 for staging studies. Iodine 124 (I-124) is a radioisotope of iodine which emits a positron and is imaged using PET (positron emission tomography). This is a single arm prospective trial that evaluates the ability of Iodine-124 (I-124) to detect metastatic thyroid cancer compared to non-interventional, usual care I-123 and I-131 images.

Eligibility

Min Age: 13 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of specialized imaging scans — I-124 PET/CT versus the more common I-123 SPECT — to see which one is better at detecting thyroid cancer that has spread or recurred after surgery. Both scans use radioactive iodine that thyroid cancer cells absorb, but PET/CT may give more detailed pictures. **You may be eligible if...** - You are 18 or older - You have differentiated thyroid cancer (the most common type) that has been confirmed by tissue analysis - You have had your entire thyroid removed - Your doctor suspects your cancer may have spread (e.g., elevated thyroglobulin levels or spots seen on earlier scans) - You are planning to undergo I-131 treatment or considering local therapy like surgery or radiation - You are scheduled for an I-123 scan within 45 days of enrolling **You may NOT be eligible if...** - You are pregnant - You are unlikely to follow the study procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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