Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate

This study is comparing two techniques used during colonoscopy to help doctors find polyps (small growths) in the colon more easily: a special camera filter called linked-color imaging (LCI) versus spraying a blue dye (indigo carmine) directly onto the bowel wall. Researchers want to see which method is better at detecting polyps that could turn into cancer. **You may be eligible if...** - You are between 45 and 85 years old - You have a personal history of colon polyps or a close family member with colon cancer or polyps - You have bowel symptoms like stomach pain, blood in stool, persistent diarrhea, constipation, unexplained weight loss, or anemia - Your at-home stool test came back positive **You may NOT be eligible if...** - You are pregnant, have inflammatory bowel disease, or are suspected to have colon cancer - You have bowel obstruction or a clotting disorder - You take blood thinners (like aspirin or clopidogrel) within 7 days before the procedure - You have previously had part of your colon surgically removed - Your bowel preparation for the colonoscopy was inadequate Talk to your doctor to see if this trial is right for you.