RecruitingNot ApplicableNCT06961916

Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 2)


Sponsor

The University of Texas Health Science Center, Houston

Enrollment

120 participants

Start Date

Jun 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from H coil combined with cognitive training for improving white matter integrity.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a type of non-invasive brain stimulation called transcranial magnetic stimulation (TMS) — which uses magnetic pulses to stimulate specific areas of the brain — can improve brain connectivity and symptoms in people with schizophrenia. Researchers will combine TMS with brain scans (MRI) to measure brain changes. **You may be eligible if...** - You are between 18 and 60 years old - You have been diagnosed with a schizophrenia-spectrum disorder - You are capable of giving informed consent (assessed by a brief screening) **You may NOT be eligible if...** - You have a history of seizures - You have had a recent stroke, significant head injury, brain surgery, or brain tumor - You take more than 400mg of clozapine per day without anti-seizure medication - You have a history of significant alcohol or drug use in the past 6 months - You have a history of blood clots or conditions that raise clotting risk - You are pregnant - You have metal implants in your body incompatible with MRI (e.g., pacemaker) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive rTMS

Active H-coil delivered rTMS sessions will be given three times per treatment visit for up to 10 visits within about 2 weeks. There are about 30 minutes breaks between adjacent TMS sessions. Each TMS session takes about 3 to 4 minutes to complete.

BEHAVIORALCognitive Training

For the cognitive training sessions, patients will be asked to play cognitive computer games involving processing speed tasks for about 15 to 30 minutes.


Locations(1)

The University of Texas Health Science Center, Houston

Houston, Texas, United States

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NCT06961916


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