RecruitingNCT06962059

Healthy Volunteers Study

Vaginal Metabolome Healthy Volunteers Study


Sponsor

Abramson Cancer Center at Penn Medicine

Enrollment

50 participants

Start Date

Apr 21, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to examine the role of the bacterial environments and metabolites in the early detection and prediction of ovarian cancer development. Vaginal swabs and stool samples will be collected from healthy volunteers, or those without a known ovarian cancer diagnosis or genetic ovarian cancer risk. These samples will be compared to samples from participants with increased cancer risk and ovarian cancer diagnoses.


Eligibility

Sex: FEMALEMin Age: 30 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting biological samples (such as blood or urine) from healthy women with ovaries in order to study digital and molecular markers that may one day help predict ovarian cancer risk earlier. This is a research study — no treatment is being tested. **You may be eligible if...** - You are a healthy adult woman with ovaries - You have no prior cancer diagnosis or treatment - You are not currently using hormone replacement therapy (HRT) - You have not taken antibiotics in the past month - You do not carry high-risk genetic mutations for ovarian cancer - Your genetic status for relevant mutations is known **You may NOT be eligible if...** - You carry gene mutations linked to ovarian cancer (such as BRCA1, BRCA2, BRIP1, PALB2, or Lynch syndrome genes) - Your genetic testing results are unknown or missing - You have had a prior cancer diagnosis or cancer treatment - You currently use hormone replacement therapy - You have used antibiotics in the past month Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSelf-Administered Sample Collection

Participants will collect vaginal swabs and a stool sample.


Locations(1)

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

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NCT06962059


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