RecruitingNCT06962059
Healthy Volunteers Study
Vaginal Metabolome Healthy Volunteers Study
Sponsor
Abramson Cancer Center at Penn Medicine
Enrollment
50 participants
Start Date
Apr 21, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to examine the role of the bacterial environments and metabolites in the early detection and prediction of ovarian cancer development. Vaginal swabs and stool samples will be collected from healthy volunteers, or those without a known ovarian cancer diagnosis or genetic ovarian cancer risk. These samples will be compared to samples from participants with increased cancer risk and ovarian cancer diagnoses.
Eligibility
Sex: FEMALEMin Age: 30 YearsMax Age: 50 Years
Inclusion Criteria1
- has ovaries
Exclusion Criteria6
- genetic mutations which increase risk of ovarian cancer: BRCA1/2, BRIP1, PALB2, Lynch Syndrome (MLH1, MSH2/EPCAM, MSH6) and ATM
- no genetic testing results or unknown genetic status
- prior cancer diagnosis
- prior cancer treatment
- HRT use
- Antibiotic use (1 month prior to providing sample)
Interventions
OTHERSelf-Administered Sample Collection
Participants will collect vaginal swabs and a stool sample.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06962059
Related Trials
Observational, Bi-directional (Prospective and Retrospective) Study for Patients With Newly Diagnosed Ovarian Cancer Stages IA to IVB, or Persistent or Recurrent Disease From January 2021; Irrespective of Histology
NCT071674331 location
Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors
NCT074245475 locations
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT0465706879 locations
Prehabilitation for EOC, Fallopian Tube, Primary Peritoneal Carcinoma and Pancreatic Cancer w/ NACT
NCT064125101 location
ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors
NCT0697316127 locations