RecruitingNCT06963203

Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis

Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis: Is it Still Necessary to Achieve a Preoperative Euthyroid State? - A Prospective Observational Multicenter European Study (GRATES)


Sponsor

Andrea Goldmann

Enrollment

486 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to learn about the potential differences in morbidity of thyroidectomy (removal of the thyroid gland) depending on the preoperative hormonal status. The main question it aims to answer is: Do patients undergoing thyroidectomy for thyreotoxicosis (thyroid hyperfunction) due to Graves' disease or Amiodarone induced thyreotoxicosis have comparable complication rates depending on their thyroid metabolic status prior or during the procedure. The data from participants undergoing a thyroidectomy at one of the study sites will be prospectively registered in the EUROCRINE registry, including an add-on module for additional study specific routine data. The operation itself, the preoperative or postoperative treatments are not altered in any way.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • Adult patients (≥ 18 years of age) undergoing surgical treatment for Graves' disease or Amiodarone-induced thyrotoxicosis (AIT) with biochemically confirmed hyperthyroidism or on specific medication for the treatment of Graves' disease or AIT.
  • Patients providing signed informed consent.

Exclusion Criteria5

  • Children and minors (<18 years).
  • Pregnant women.
  • Patients unable or unwilling to provide informed consent due to language barriers or intellectual limitations.
  • Patients undergoing concurrent parathyroidectomy for primary or secondary hyperparathyroidism, lymph node clearance, or redo surgery.
  • Surgical procedures performed for other reasons than Graves' disease or AIT

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Locations(15)

OLV Ziekenhuis

Aalst, Belgium

Universite de Lorraine, Cru Nancy

Nancy, France

Evgenidion Hospital Athens

Athens, Greece

Universitario Virgen de las Nieves

Granada, Spain

Hospital Costa del Sol

Marbella, Spain

Kantonsspital Winterthur

Zurich, Winterthur, Switzerland

Clarunis St. Clara Spital

Basel, Switzerland

Universitätsspital Bern, Inselspital

Bern, Switzerland

University Hospitals of Geneva

Geneva, Switzerland

University Hospital of Lausanne CHUV

Lausanne, Switzerland

Kantonsspital Basel Land

Liestal, Switzerland

Spital Männedorf

Männedorf, Switzerland

Ospedale Regionale di Mendrisio

Mendrisio, Switzerland

HOCH Kantonsspital St. Gallen

Sankt Gallen, Switzerland

Spital Limmattal

Schlieren, Switzerland

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NCT06963203


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