Evaluate Efficacy, Safety, Tolerability and Biodegradation of PA5346 Ocular Implant in Patients With Open-Angle Glaucoma or Ocular Hypertension

This study is testing a new tiny implant placed in the eye (called PA5346) to lower eye pressure in people with glaucoma or high eye pressure, as an alternative to daily eye drops. **You may be eligible if...** - You are 18 or older - You have been diagnosed with open-angle glaucoma or high eye pressure (ocular hypertension) in both eyes - Your eye pressure falls within a qualifying range after stopping any current eye pressure medications - You have adequate vision and eye cell health (corneal endothelial cell density) - You are able to understand and follow study instructions **You may NOT be eligible if...** - You have had recent eye surgery - You have certain other eye conditions that could affect the results - You are on medications that cannot be stopped for the washout period Talk to your doctor to see if this trial is right for you.