RecruitingNot ApplicableNCT06964425

Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study

Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma

Sponsor

University Hospital Olomouc

Enrollment

20 participants

Start Date

Feb 4, 2023

Study Type

INTERVENTIONAL

Conditions

Diagnosis Raman Spectroscopy Biliary Stricture Endoscopy Klatskin Tumor Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma of the Extrahepatic Bile Duct Cholangiocarcinoma, Perihilar Malignant Biliary Stricture

Summary

Diagnosis of extrahepatic cholangiocarcinoma is challenging because the yield of imaging and tissue sampling is limited. Raman spectroscopy is an optical method based on the analysis of scattered monochromatic light. Raman spectroscopy is able to provide a molecular 'fingerprint' of the tissue to determine its type. The aim of this pilot study was to develop a methodology for in vivo Raman spectroscopy in bile ducts to improve the current diagnostic capabilities of extrahepatic cholangiocarcinoma.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

person older than 18 years, who has known extrahepatic cholangiocarcinoma and is indicated for ERCP

Exclusion Criteria1

disagreement with the study

Interventions

PROCEDUREEndoscopic retrograde cholangiopancreatography (ERCP)

Insertion of a endoscopic fiber-optic Raman probe under fluoroscopic control during endoscopic retrograde cholangiopancreatography to measure Raman spectra of extrahepatic cholangiocarcinoma and healthy bile duct.