RecruitingNot ApplicableNCT06964425

Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study

Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma

Sponsor

University Hospital Olomouc

Enrollment

20 participants

Start Date

Feb 4, 2023

Study Type

INTERVENTIONAL

Conditions

Diagnosis Raman Spectroscopy Biliary Stricture Endoscopy Klatskin Tumor Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma of the Extrahepatic Bile Duct Cholangiocarcinoma, Perihilar Malignant Biliary Stricture

Summary

Diagnosis of extrahepatic cholangiocarcinoma is challenging because the yield of imaging and tissue sampling is limited. Raman spectroscopy is an optical method based on the analysis of scattered monochromatic light. Raman spectroscopy is able to provide a molecular 'fingerprint' of the tissue to determine its type. The aim of this pilot study was to develop a methodology for in vivo Raman spectroscopy in bile ducts to improve the current diagnostic capabilities of extrahepatic cholangiocarcinoma.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a pilot study testing whether a special light-based analysis tool (Raman spectroscopy) can detect bile duct cancer (called cholangiocarcinoma) during a standard procedure called ERCP — where a small camera is guided into the bile duct through the mouth. **You may be eligible if...** - You are over 18 years old - You have a known diagnosis of cancer in the bile duct outside the liver (extrahepatic cholangiocarcinoma) - You are already scheduled for an ERCP procedure **You may NOT be eligible if...** - You do not agree to participate in the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEndoscopic retrograde cholangiopancreatography (ERCP)

Insertion of a endoscopic fiber-optic Raman probe under fluoroscopic control during endoscopic retrograde cholangiopancreatography to measure Raman spectra of extrahepatic cholangiocarcinoma and healthy bile duct.