RecruitingNCT06965023

Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

Sponsor

Azienda Ospedaliera "Sant'Andrea"

Enrollment

130 participants

Start Date

Apr 22, 2025

Study Type

OBSERVATIONAL

Conditions

Pollution; Exposure ST-elevation Myocardial Infarction (STEMI)Microplastics Nanoplastics

Summary

Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether tiny plastic particles found in our environment (called microplastics and nanoplastics) are present in the blood clots of people who have had a certain type of heart attack called STEMI — where a coronary artery is completely blocked. **You may be eligible if...** - You are over 18 years old - You are having a STEMI (heart attack caused by a complete coronary artery blockage) - You are undergoing urgent heart catheterization and there is clinical need for a procedure to suction out the blood clot - You are able to give informed consent **You may NOT be eligible if...** - There are medical reasons you cannot have a coronary intervention - You are in cardiogenic shock (heart not pumping well enough to sustain the body) - You have severe kidney disease - Your life expectancy is less than one year Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(10)

Sant'Andrea University Hospital

Roma, Rome, Italy

Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli

Caserta, Italy

Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy.

Caserta, Italy

Cardiovascular Department, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.

Catania, Italy

Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy

Ferrara, Italy

Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy.

Forlì, Italy

Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy.

Milan, Italy

Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy.

Naples, Italy

Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy.

Turin, Italy

Azienda Ospedaliera Integrata Verona, Italy

Verona, Italy

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NCT06965023

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