RecruitingPhase 1NCT06966024

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

An Open-label, Phase 1 Study of DCC-2812 Monotherapy in Participants With Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer


Sponsor

Deciphera Pharmaceuticals, LLC

Enrollment

60 participants

Start Date

Aug 27, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an investigational oral drug called DCC-2812 in people with advanced genitourinary cancers — including kidney cancer, bladder/urinary tract cancer, or prostate cancer that no longer responds to hormone therapy. **You may be eligible if...** - You have confirmed advanced or metastatic renal cell carcinoma, urothelial cancer, or castration-resistant prostate cancer - You are able to swallow oral medication - Your organ function meets the required thresholds - If female and able to become pregnant, you have had a negative pregnancy test and will use contraception **You may NOT be eligible if...** - You have had recent anticancer treatment or an investigational therapy within the required timeframe - You have significant heart problems - You had major surgery within the past 28 days Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDCC-2812

Administered orally


Locations(4)

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Vanderbilt- Ingram Cancer Center

Nashville, Tennessee, United States

NEXT Oncology, Austin

Austin, Texas, United States

NEXT Oncology, San Antonio

San Antonio, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT06966024


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