RecruitingPhase 3NCT06966206

Multiprofen-CC to Reduce Pain in Hand Arthritis

Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial

Sponsor

St. Joseph's Healthcare Hamilton

Enrollment

42 participants

Start Date

Mar 9, 2026

Study Type

INTERVENTIONAL

Conditions

Hand Osteoarthritis

Summary

This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects. Participants will: * Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order. * Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions. * Attend a visit before starting the study, after 2 weeks, and after 6 weeks. * Report any symptoms they experience during the study.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Adults (18+)
Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria
Experience pain and/or loss of function in one or both hands that interferes with daily life
Provide informed consent

Exclusion Criteria9

Unable to consent
Unable or unwilling to follow study protocol
Known allergy or contraindication to any of the study drugs or their ingredients
Have open wounds/cuts and/or skin conditions on the hand area
Pregnant or breastfeeding
History of impaired kidney or liver function
Rheumatoid or other inflammatory arthropathy
Hand surgery within the past 6 months or planned within the study period.
Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis