RecruitingPhase 3NCT06969287

Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery

Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery (MD FluNCS)

Sponsor

Washington University School of Medicine

Enrollment

46 participants

Start Date

Apr 6, 2026

Study Type

INTERVENTIONAL

Conditions

Delirium

Summary

The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients undergoing non-cardiac non-intracranial surgery.

Eligibility

Min Age: 60 Years

Inclusion Criteria2

English-speaking
elective non-cardiac or non-intracranial surgery requiring at least a 2-day hospital length of stay

Exclusion Criteria7

Received investigational drug within the last 7 weeks
lack of capacity to provide informed consent
prior known intolerance or allergy to SSRIs or fluvoxamine
planned postoperative ventilation
drug or alcohol dependence
preoperative use of non-NSAID medications with drug-drug interactions of Class X (Avoid Combination) or D (Consider Therapy Modification)
risk of serotonin syndrome (St John's Wort, SSRIs, or TCA)

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Interventions

DRUGFluvoxamine

100mg Fluvoxamine Capsule 1. Day of surgery - Study drug to be taken morning of surgery and evening of surgery 2. Post-operative day 1 - Study drug to be taken morning and evening

DRUGPlacebo

Placebo Capsule 1. Day of surgery - Study drug to be taken morning of surgery and evening of surgery 2. Post-operative day 1 - Study drug to be taken morning and evening