RecruitingNot ApplicableNCT06971991

qDSA Blood Flow Measurement in Patients Undergoing TAE of the Liver

qDSA Blood Flow Measurement in Patients Undergoing Transarterial Embolization (TAE) of the Liver

Sponsor

University of Wisconsin, Madison

Enrollment

20 participants

Start Date

Mar 13, 2025

Study Type

INTERVENTIONAL

Conditions

Radioembolization Transarterial Chemoembolization Transarterial Embolism

Summary

The purpose of this research is to evaluate a new technique, quantitative digital subtraction angiography (qDSA), to measure blood flow during liver embolization procedures. Liver embolization is a way of treating liver tumors by blocking blood flow to it. The qDSA technique could help doctors ensure the blood flow to the tumor is decreased by the right amount by calculating blood flow before, during, and after the procedure. Up to 20 participants will be enrolled for 1 study visit and data collection for up to 6 months.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

Give voluntary, written informed consent to participate in this study and willing to comply with study-related evaluation and procedure schedule

Exclusion Criteria5

Pregnancy or breastfeeding
Patients with an acute kidney injury or stage IV or V chronic kidney disease (Cr greater than 2.4 or estimated glomerular filtration rate (eGFR) less than 30), unless anuric and on dialysis without expected return of renal function.
Patients with an iodinated contrast allergy who cannot be adequately premedicated to receive contrast as part of the embolization procedure.
Patients with a physical or psychological condition that would impair study participation.
The patient is judged unsuitable for study participation by the Investigator for any other reason

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Interventions

DEVICEqDSA Blood Flow Measurement

Pre-, mid-, and post-embolization, qDSA and transabdominal US Doppler images will be acquired for research purposes during TAE and TACE procedures. For patients undergoing radioembolization, qDSA and US Doppler images will be acquired during both the preparatory angiogram and therapy angiogram (prior to delivery of the radioactive particles)