Post-Stroke Aphasia TMS
Precision Neuromodulation in Post-Stroke Aphasia Using TMS
Medical College of Wisconsin
50 participants
Sep 1, 2025
INTERVENTIONAL
Conditions
Summary
The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).
Eligibility
Inclusion Criteria4
- Diagnosed with left hemisphere stroke
- Consent date \>= 1 month after stroke onset
- Fluent in English
- years of age or older
Exclusion Criteria9
- Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
- Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
- A chronic medical condition that is not treated or is unstable
- The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips)
- Pregnancy
- History of skull fractures, or skin diseases
- History of ongoing or unmanaged seizures
- Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
- History of dyslexia or other developmental learning disabilities
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Interventions
Excitatory TMS delivered using a precision site finding approach and intermittent theta burst stimulation protocol
Excitatory TMS using intermittent theta burst stimulation delivered to a control vertex site.
Locations(1)
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NCT06974279