Aphasia Clinical Trials

88 recruitingLast updated: June 18, 2026

There are 88 actively recruiting aphasia clinical trials across 15 countries. Studies span Not Applicable, Phase 2, Early Phase 1, Phase 4. Top locations include Philadelphia, Pennsylvania, United States, Toronto, Ontario, Canada, Baltimore, Maryland, United States. Updated daily from ClinicalTrials.gov.


Aphasia Trials at a Glance

88 actively recruiting trials for aphasia are listed on ClinicalTrialsFinder across 6 cities in 15 countries. The largest study group is Not Applicable with 57 trials, with the heaviest enrollment activity in Philadelphia, Toronto, and Baltimore. Lead sponsors running aphasia studies include Changping Laboratory, Johns Hopkins University, and Medical College of Wisconsin.

Browse aphasia trials by phase

Treatments under study

About Aphasia Clinical Trials

Looking for clinical trials for Aphasia? There are currently 63 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Aphasia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Aphasia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 88 trials

Recruiting
Not Applicable

Stimulating the Aging Brain Using Brain and Sensory Stimulation

Primary Progressive Aphasia
Medical College of Wisconsin20 enrolled1 locationNCT07650188
Recruiting
Early Phase 1

Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

DementiaAlzheimer DiseaseProgressive Aphasia+3 more
University of Texas at Austin120 enrolled1 locationNCT06511752
Recruiting
Not Applicable

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

DementiaAlzheimer DiseaseCommunication Disorders+11 more
Stephanie Grasso60 enrolled3 locationsNCT05741853
Recruiting
Phase 2

Communication Bridge 3 Study

Primary Progressive Aphasia
University of Chicago200 enrolled1 locationNCT06191198
Recruiting
Not Applicable

Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe

StrokeAphasia
University of South Carolina45 enrolled1 locationNCT07608588
Recruiting
Not Applicable

Neural Bases of Vocal Sensorimotor Impairment in Aphasia

Aphasia
The University of Texas at Dallas100 enrolled3 locationsNCT04742894
Recruiting
Not Applicable

Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.

StrokeAphasia
University of New Mexico50 enrolled1 locationNCT04432883
Recruiting
Not Applicable

LEXURE for Post-Stroke Aphasia

Aphasia
Nunaps Inc116 enrolled12 locationsNCT07570264
Recruiting
Early Phase 1

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting
Not Applicable

Remotely-supervised Neuromodulation in PPA

Primary Progressive Aphasia(PPA)Progressive AphasiaProgressive Aphasia in Alzheimer's Disease+3 more
Maya Henry80 enrolled2 locationsNCT07260253
Recruiting
Phase 2

Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

Primary Progressive AphasiaLogopenic Progressive AphasiaNon-Fluent Primary Progressive Aphasia
Johns Hopkins University180 enrolled3 locationsNCT05386394
Recruiting
Not Applicable

Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia

Aphasia
University of Massachusetts, Amherst160 enrolled1 locationNCT06990997
Recruiting
Not Applicable

Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech

Aphasia, Primary ProgressiveStuttering, Developmental
Boston University Charles River Campus2 enrolled3 locationsNCT05437159
Recruiting
Phase 2

Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

StrokeAphasiaAphasia Following Cerebral Infarction
University of Pennsylvania63 enrolled1 locationNCT06968663
Recruiting

The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

Apraxia of SpeechPrimary Progressive AphasiaNon-fluent Aphasia+1 more
Mayo Clinic47 enrolled1 locationNCT03313011
Recruiting
Phase 2

Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia

Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
EIP Pharma Inc20 enrolled7 locationsNCT07033481
Recruiting
Not Applicable

Long Term Effect of Brain Stimulation in PPA

Primary Progressive Aphasia(PPA)
Hospital San Carlos, Madrid80 enrolled1 locationNCT07158216
Recruiting
Not Applicable

Intervention for Communication Quality of Life in Primary Progressive Aphasia

Primary Progressive Aphasia(PPA)Progressive AphasiaLogopenic Progressive Aphasia (LPA)+9 more
Maya Henry30 enrolled1 locationNCT07219680
Recruiting
Not Applicable

Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia

StrokeAphasiaAphasia Non Fluent
University of South Florida20 enrolled2 locationsNCT06829420
Recruiting
Phase 2

Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia

StrokeAphasia
University of Pittsburgh30 enrolled1 locationNCT05653440