RecruitingNot ApplicableNCT06974994

Resilience to Antibiotic-induced Obesogenic Microbiota: Discovering Mechanism of Microbiota Modulation

Resilience to Antibiotic-induced Obesogenic Microbiota Vertically Transferred to the Neonatal Gut: Discovering Mechanism of Microbiota Modulation


Sponsor

Turku University Hospital

Enrollment

125 participants

Start Date

May 8, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim is to study whether the microbiota of children who are exposed to antibiotics at birth could be modified by synbiotic supplement and thereby reduce the risk of obesity, chronic diseases and respiratory tract infections. A total of 125 mother-child pairs will be recruited in this randomized, double-blind, placebo-controlled study. Infants are randomized to receive either a synbiotic supplement or a placebo for 2 months, after which their growth and morbidity will be monitored at the research clinic for 2 years.


Eligibility

Min Age: 2 Hours

Inclusion Criteria1

  • Pregnant women (n=125) and their newborn children who receive antibiotic treatment at delivery.

Exclusion Criteria4

  • Chorioamnionitis
  • Pre-eclampsia and hepatogestosis
  • Suspected malformation or serious condition of the foetus and neonates
  • Serious infection or other conditions not permitting breast milk feeding

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Interventions

DIETARY_SUPPLEMENTSynbiotic Supplement

Bifidobacterium bifidum and human milk oligosaccharides (HMOs)

OTHERPlacebo

Maltodextrin


Locations(1)

Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku

Turku, Valitse Maakunta., Finland

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NCT06974994