Adverse Adolescent Pathways to Substance Use

This study is looking at how stress and anxiety in early adolescence may influence the development of substance use habits. Researchers will use brain imaging and stress tests to understand how teens process stress, which may help develop better prevention programs. **You may be eligible if...** - You are between 12 and 14 years old - You report symptoms of anxiety - You have never used alcohol, tobacco, or marijuana (or used any of these no more than twice) - You can read and understand English, and a parent can sign a consent form - You meet the study's hearing and vision requirements **You may NOT be eligible if...** - You have any metal implants or devices in your body that cannot be removed (for MRI safety) - You have been diagnosed with psychosis or a severe emotional disorder - You have used alcohol, tobacco, or marijuana more than 3 times - You are pregnant - You take medications that directly affect heart rate or cardiovascular function - You have ever taken antipsychotic medication - You have had a head injury with more than 5 minutes of unconsciousness - You have an intellectual disability (IQ below 70) Talk to your doctor to see if this trial is right for you.