RecruitingNot ApplicableNCT06979284

Intravascular Ultrasound for Peripheral Artery Disease Revascularization

Intravascular Ultrasound for Peripheral Artery Disease Revascularization: The CLARITY Randomized Controlled Trial

Sponsor

Hamilton Health Sciences Corporation

Enrollment

772 participants

Start Date

Dec 5, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Limb Threatening Ischemia Peripheral Arterial Disease(PAD)Restenosis Intravascular Ultrasound Major Adverse Limb Events

Summary

The purpose of this study is to determine if IVUS use, as compared to angiography alone, prevent major adverse limb events (MALE) or binary restenosis (a greater than 50% re-narrowing of the treated artery) in adult patients who have CLTI and are undergoing percutaneous revascularization.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called IVUS-guided strategy for people with chronic limb threatening ischemia, intravascular ultrasound, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREIVUS-guided strategy

Percutaneous revascularization will be performed using intravascular ultrasound. The operators will follow instructions to modify arteries hardened by calcium and use IVUS to optimize the equipment (balloon and stents) used to unblock the artery.