RecruitingPhase 2NCT06982508

Evaluation of Obicetrapib on Antioxidant Levels in Plasma and HDL Particles of Healthy Volunteers

A Randomized, Double-Blind, Placebo-Controlled Parallel Trial to Assess the Effects of Obicetrapib on Levels of Antioxidants in Plasma and HDL Particles in Healthy Volunteers: The VERMEER Study


Sponsor

NewAmsterdam Pharma

Enrollment

100 participants

Start Date

Sep 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if Obicetrapib works to change antioxidant levels in HDL and plasma, as well as retinal tissue. The main questions it aims to answer are: Do Obicetrapib effect absorption of antioxidants in a person's blood or their eye tissue? Researchers will compare Obicetrapib to a placebo (a look-alike substance that contains no drug) to see if Obicetrapib helps improve a person's ability to absorb antioxidants. Participants will: Take Obicetrapib or a placebo every day for 4 months Visit the clinic once every 8 weeks for checkups and tests Have their blood taken and their eyes checked to measure antioxidant levels


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria1

  • Visual acuity > 20/60 in both eyes with or without corrective lenses

Exclusion Criteria3

  • Type 2 diabetes
  • Active liver disease
  • Any clinically significant macular pathology

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Interventions

DRUGObicetrapib 10mg

Active Drug

DRUGPlacebo

Placebo Control


Locations(1)

Excellence Medical Research

Miami Gardens, Florida, United States

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NCT06982508