Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia

This study is testing a brain-computer interface (BCI) approach called "self neuromodulation therapy" for people with major depression who also experience anhedonia — a loss of pleasure or interest in activities. Participants wear a headset that records brain activity and receive feedback to help train their brains to shift toward healthier patterns of activity. **You may be eligible if...** - You are an adult diagnosed with major depressive disorder (MDD) with anhedonia - You have moderately severe depression (score of 20 or above on a standard rating scale) and significant anhedonia - You have tried at least one antidepressant medication at an adequate dose and duration during your current episode - You can speak and read English fluently, have normal or corrected vision and hearing **You may NOT be eligible if...** - You have metal implants in your body or claustrophobia (which prevents MRI scanning) - You have had a suicide attempt or self-harm behavior in the past year - You currently have moderate or severe substance or alcohol use disorder - You have an unstable medical condition that could interfere with the study Talk to your doctor to see if this trial is right for you.