Efficacy and Safety of Photodynamic Therapy for Cervical and Vaginal Intraepithelial Neoplasia

This study is testing photodynamic therapy (PDT) — a treatment that uses light-activated medication to destroy abnormal cells — for high-grade cervical or vaginal precancerous lesions (called CIN2, CIN3, VaIN2, or VaIN3). PDT is a less invasive alternative to surgical procedures and may preserve more healthy tissue. **You may be eligible if...** - You have been diagnosed with high-grade precancerous lesions in your cervix or vagina (CIN2/CIN3 or VaIN2/VaIN3), confirmed by colposcopy and biopsy - OR you have had persistent low-grade lesions (CIN1/VaIN1) for more than one year and wish to have them treated - Your colposcopy was adequate and your sampling of the cervical canal (ECC) did not show higher-grade disease **You may NOT be eligible if...** - There is any suspicion or confirmed diagnosis of cancer (not just precancerous cells) - You have a rare condition called porphyria, or an allergy to red or blue light - You have severe health conditions that make treatment unsafe Talk to your doctor to see if this trial is right for you.