Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance
FIT Versus Colonoscopy for Post-polypectomy Surveillance
Sorlandet Hospital HF
4,000 participants
Jan 9, 2026
INTERVENTIONAL
Conditions
Summary
From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.
Eligibility
Inclusion Criteria4
- High-quality baseline colonoscopy with adequat cleansing and cecal intubation
- Remocval of at least one advanced adenoma
- Clean colon (all polyps removed)
- Signed informed consent
Exclusion Criteria7
- Colorectal cancer
- History of surgical colon resection for any reason
- Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome)
- ≥ 10 adenomas at baseline colonoscopy (cumulative)
- History of advanced serrated lesion, defined as SSL≥ 10mm or with dysplasia
- Inflammatory bowel disease
- On-going palliative care for any reason
Interventions
Colonoscopy after polyp removal according to guidelines
Fecal testing for blood as surveillance efter polyp removal
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06983639