RecruitingNot ApplicableNCT06983639

Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance

FIT Versus Colonoscopy for Post-polypectomy Surveillance

Sponsor

Sorlandet Hospital HF

Enrollment

4,000 participants

Start Date

Jan 9, 2026

Study Type

INTERVENTIONAL

Conditions

Colorectal Neoplasms

Summary

From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.

Eligibility

Min Age: 40 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial compares annual stool testing (FIT) to colonoscopy every 3–5 years as a follow-up strategy after having a pre-cancerous colon polyp removed, to see which approach best prevents colorectal cancer. **You may be eligible if...** - You have had a high-quality colonoscopy where at least one advanced polyp was completely removed - Your colon was fully cleaned during the procedure and the entire colon was examined - You have signed informed consent **You may NOT be eligible if...** - You have colorectal cancer - You have had colon surgery - You have a genetic cancer syndrome (such as Lynch syndrome or polyposis) - You had 10 or more adenomas found at baseline - You have a history of large or pre-cancerous serrated polyps - You have inflammatory bowel disease - You are currently on palliative care Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.