RecruitingEarly Phase 1NCT06983730

The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress

Sponsor

Beth Israel Deaconess Medical Center

Enrollment

28 participants

Start Date

Jan 26, 2026

Study Type

INTERVENTIONAL

Conditions

Heat Strain Healthy Volunteer Study Kidney Dysfunction

Summary

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how exercising in hot conditions affects kidney function, and whether taking vitamin B3 (niacin) beforehand can protect the kidneys. Exercise in heat can temporarily stress the kidneys, and vitamin B3 may help reduce this by improving blood flow. Participants will exercise in a heated environment and have kidney function measured before and after. **You may be eligible if...** - You are a healthy adult of any race - Your kidneys function normally (eGFR above 90, urine albumin below 30) - You are a nonsmoker - You are physically active with a moderate fitness level (VO2 max between 35–60 mL/kg/min) - You do not take regular dietary supplements, especially vitamin B3 **You may NOT be eligible if...** - You have a medical condition that makes it unsafe to exercise in the heat - You have an allergy to vitamin B3 - You have severe food allergies or dietary restrictions that would prevent following the study diet Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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