The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress
Beth Israel Deaconess Medical Center
28 participants
Jan 26, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?
Eligibility
Inclusion Criteria7
- Healthy volunteer
- Any race
- Estimated glomerular filtration rate greater than 90 ml/min/1.73m2
- Urine albumin/creatinine ratio less than 30mg/g
- Nonsmoker
- No regular dietary supplements, particularly vitamin B3
- Physically fit, defined as having a VO2 max of between 35 and 60mL/kg/min
Exclusion Criteria3
- Medical condition preventing safe participation in exercise during heat
- Allergy to Vitamin B3
- Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications
Interventions
1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06983730