Exercise Training for the Improvement of Immune Activity and Treatment Outcomes During Immunotherapy for Non-small Cell Lung Cancer, BOOST Trial

This study (the BOOST Trial) is testing whether a structured exercise program can improve immune function and treatment outcomes in people with non-small cell lung cancer (NSCLC) who are currently receiving immunotherapy. Many lung cancer patients are not very physically active, and exercise may help the immune system work better alongside these treatments. **You may be eligible if...** - You are 18 or older with a histologically confirmed NSCLC diagnosis - You are currently receiving immunotherapy and have completed at least one month of treatment - You plan to continue immunotherapy for at least 24 more weeks - You are currently doing less than 150 minutes of moderate-to-vigorous exercise per week - You are in good enough physical condition to participate in fitness assessments **You may NOT be eligible if...** - You are already regularly exercising 150 minutes or more per week - You have an unstable or uncontrolled medical condition that makes exercise unsafe (e.g., recent heart attack, bone fractures) - You are unable to safely participate based on a physical activity readiness questionnaire Talk to your doctor to see if this trial is right for you.