Adaptive Radiation for Locally Advanced Unresectable Pancreatic Cancer

This study is testing a type of radiation therapy called adaptive radiation therapy (ART) for people with locally advanced pancreatic cancer that cannot be surgically removed. Adaptive radiation uses real-time imaging during each treatment session to adjust the radiation beams around the tumor — potentially delivering higher, more effective doses while protecting nearby organs like the stomach and intestines. **You may be eligible if...** - You have been confirmed by biopsy or cytology to have pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer) - Your cancer is locally advanced and cannot be surgically removed (as determined by a multidisciplinary team including a pancreatic surgeon) - You have received or been evaluated for induction chemotherapy before radiation - You are in adequate physical condition to tolerate the treatment **You may NOT be eligible if...** - Your cancer has already spread to other organs (metastatic disease) - You have had prior radiation to the same area of the abdomen - You are unable to complete the required imaging and treatment sessions due to health limitations - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.