RecruitingNot ApplicableNCT06986122

Virtual Contexts for Affective Modulation

Controllability of Virtual Contexts for the Modulation of the Affective Experience


Sponsor

Trustees of Dartmouth College

Enrollment

20 participants

Start Date

Oct 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior. The study examines how control over pain and threat-related environments influences pain perception, state anxiety, associated autonomic responses, and behavior. The main questions it aims to answer are: Does having control over pain within specific contexts alter how much pain people feel-even when the stimulus intensity remains constant? How do different types of environments (safe, controllable, or uncontrollable) shape pain-related brain activity, subjective anxiety, and physiological arousal? How do people perform cognitively demanding or distracting tasks (and retain their memory) when under threat versus when in control? Lastly, how do these learned associations with spatial contexts persist or adapt when environmental contingencies are explicitly changed? Taken together, exploration of these factors may lay the groundwork for understanding how placebo-related mechanisms-including perceived control, contextual learning, emotional engagement, and distraction-interact to shape pain and anxiety in complex environments.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This research study is exploring how virtual reality environments affect emotions and brain activity. It is a brain imaging study (using MRI) designed to understand how the context of an experience influences emotional responses in healthy volunteers. **You may be eligible if...** - You are a healthy adult with no current or past mental health conditions - You have no history of seizures in the last 10 years, stroke, or major neurological illness - You have no chronic pain or acute pain in the last 3 months - You do not take any medications that affect the brain or nervous system - You have no substance abuse history in the last 6 months - You have no contraindications to MRI (no pacemakers, metal implants, claustrophobia, etc.) **You may NOT be eligible if...** - You have or have had depression, bipolar disorder, or any other psychiatric diagnosis - You have a current migraine disorder - You have any condition that prevents safe MRI scanning Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPain Threat Manipulation

Participants receive brief thermal pain stimuli in certain virtual environments to examine how threat influences perception and physiological responses.

BEHAVIORALPain Controllability Manipulation

In some contexts, participants can reduce or avoid pain using a button; in others, no action changes the outcome. This manipulation is used to study the effects of perceived control over pain.


Locations(1)

Dartmouth College

Hanover, New Hampshire, United States

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NCT06986122


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