RecruitingNot ApplicableNCT06988982

Lipid Emulsion for Reversal of Spinal Anesthesia in Ambulatory Surgery

Lipid Emulsion for Reversal of Spinal Anesthesia in Ambulatory Surgery: A Randomized Controlled Trial


Sponsor

Zagazig University

Enrollment

42 participants

Start Date

Jun 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Ambulatory surgery places high demands on anesthetic technique. rapid onset and offset of anesthesia, rapid recovery of protective reflexes, mobility and micturition, are required. Since the inception of ambulatory surgery, the favored anesthetic technique has been general anesthesia with short-acting drugs. Concerns about the time to perform spinal anesthesia and the risks of prolonged motor block and urinary retention have limited its use. Alpha-blockers, lavage fluids for epidural space, insulin, and intravenous lipid emulsions, are still being discussed to shorten and reverse adverse effect of different LAs used for spinal anaesthesia, hence we will evaluate the effectiveness of intravenous lipid emulsion for reversing the neural blockade of spinal anaesthesia in patients undergoing ambulatory surgery.


Eligibility

Min Age: 21 YearsMax Age: 70 Years

Inclusion Criteria6

  • Patient acceptance.
  • Cooperative patient
  • Age 21-70 years old.
  • BMI ≤ 35 kg/m2
  • ASA I - II.
  • Elective ambulatory surgery under spinal anesthesia (general surgery, urology, gynecology, orthopedic surgery).

Exclusion Criteria4

  • History of allergy to the LA agents used in this study,
  • Skin lesion at needle insertion site,
  • Those with bleeding disorders, sepsis, liver disease and psychiatric disorders
  • History of cognitive dysfunction or mental illness

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGIntravenous Lipid Emulsion 20%

patients will receive 1.5 ml/kg bolus of intravenous lipid emulsion 20 % followed by 0.25 ml/kg/hr infusion over 30 minutes at the end of surgery

DRUGControl (placebo) group

patients will receive equal volume of normal saline at the end of surgery


Locations(1)

Zagazig University Hospitals

Zagazig, Al Sharqia, Egypt

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06988982


Related Trials