DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
DESTINY-Endometrial01: An Open-Label, Sponsor-Blinded, Randomized, Controlled, Multicenter, Phase III Study of Trastuzumab Deruxtecan (T-DXd) Plus Rilvegostomig or Pembrolizumab vs Chemotherapy Plus Pembrolizumab as First-Line Therapy of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR), Primary Advanced or Recurrent Endometrial Cancer
AstraZeneca
600 participants
Mar 27, 2025
INTERVENTIONAL
Conditions
Summary
DESTINY-Endometrial01 will investigate the efficacy of first-line T-DXd + rilvegostomig (Arm A) and/or T-DXd+ pembrolizumab (Arm B) when compared to chemotherapy (carboplatin + paclitaxel) + pembrolizumab (Arm C), by assessment of progression free survival (PFS), as assessed by BICR, in participants with HER2-expressing (IHC 3+/2+), pMMR, primary advanced (Stage III/IV) or recurrent EC.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Experimental therapy by intravenous infusion
Experimental therapy by intravenous infusion
Immunotherapy by intravenous infusion
Standard of Care (SoC) chemotherapy by intravenous infusion
Standard of Care (SoC) chemotherapy by intravenous infusion
Standard of Care (SoC) chemotherapy by intravenous infusion
Locations(250)
View Full Details on ClinicalTrials.gov
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NCT06989112