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RecruitingPhase 2NCT06991257

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF AN ORAL BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE INHIBITOR, PF-07328948, IN ADULTS WITH HEART FAILURE (BRANCH-HF)

Sponsor

Pfizer

Enrollment

620 participants

Start Date

Jun 19, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

Eligibility

Min Age: 18 YearsMax Age: 79 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new medicine called PF-07328948 in people with heart failure whose heart still pumps with a relatively preserved force — a condition called heart failure with preserved ejection fraction (HFpEF). **You may be eligible if...** - You are 18 to under 80 years old - You have had a confirmed heart failure diagnosis for at least 3 months - You have moderate to severe symptoms (NYHA Class II–IV) - Your heart pumps at more than 40% efficiency - You can walk more than 75 meters in 6 minutes **You may NOT be eligible if...** - You have type 1 diabetes, liver cirrhosis, or another condition affecting how the medicine is absorbed - You are scheduled for major surgery that would affect your walking ability - You have had a heart transplant or are on the transplant waiting list - You have had a bad reaction to a type of diabetes drug called an SGLT2 inhibitor Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPlacebo

ARM 1

DRUGLow Dose PF-07328948

ARM 2

DRUGMedium Dose PF-07328948

ARM 3

DRUGHigh Dose PF-07328948

ARM 4

Locations(135)

National Heart Institute

Beverly Hills, California, United States

Orange County Research Center

Lake Forest, California, United States

Comprehensive Cardiovascular Care

Santa Maria, California, United States

FOMAT Medical Research

Santa Maria, California, United States

FWD Clinical Research

Boca Raton, Florida, United States

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Infinite Clinical Research

Miami, Florida, United States

Flourish Research Acquisition, LLC dba Flourish Research - North Miami

Miami, Florida, United States

Amavita Research Services

North Miami Beach, Florida, United States

Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, United States

NMH Clinical Research Unit

Chicago, Illinois, United States

Northwestern Memorial HealthCare - Arkes Pavilion

Chicago, Illinois, United States

Northwestern Memorial HealthCare - Feinberg Pavilion

Chicago, Illinois, United States

Northwestern Memorial HealthCare - Galter Pavilion

Chicago, Illinois, United States

Northwestern Memorial Hospital Investigational Drug Service (IDS)

Chicago, Illinois, United States

Northwestern University

Evanston, Illinois, United States

Chicago Medical Research

Hazel Crest, Illinois, United States

NexGen Research

Fort Wayne, Indiana, United States

Reid Physician Associates

Richmond, Indiana, United States

Ascension Saint Agnes Heart Care

Baltimore, Maryland, United States

Chesapeake Cardiac Care

Bowie, Maryland, United States

Flourish Research - Bowie

Bowie, Maryland, United States

Velocity Clinical Research, Lincoln, Pioneer Heart Institute

Lincoln, Nebraska, United States

NexGen Research

Lima, Ohio, United States

Headlands Horizons, LLC dba Headlands Research-Brownsville

Brownsville, Texas, United States

Valley Regional Medical Center

Brownsville, Texas, United States

North Dallas Research Associates

McKinney, Texas, United States

Northwest Houston Heart Center

Tomball, Texas, United States

L2IP - Instituto de Pesquisas Clínicas

Brasília, Federal District, Brazil

L2IP - Instituto de Pesquisas Clínicas

Brasília, Federal District, Brazil

Cardresearch - Cardiologia Assistencial e Pesquisa

Belo Horizonte, Minas Gerais, Brazil

Núcleo de Pesquisa Clínica do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, Brazil

CoraCentro Pesquisa Clinica

Porto Alegre, Rio Grande do Sul, Brazil

Instituto de Pesquisa clinica de Campinas

Campinas, São Paulo, Brazil

Centro Avançado De Pesquisa, Estudos E Diagnóstico (CAPED) - Centro Médico RibeirãoShopping

Ribeirão Preto, São Paulo, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto

São José do Rio Preto, São Paulo, Brazil

UNESP - Faculdade de Medicina da Universidade Estadual Paulista

Botucatu, SÃO PAUL, Brazil

CEPIC - Centro Paulista de Investigação Clínica

São Paulo, Brazil

Incor - Instituto do Coracao

São Paulo, Brazil

Diagnostic Consultative Center - 1 Lom EOOD

Lom, Montana, Bulgaria

Diagnostic Consultative Center "Ascendent"

Sofia, Sofia (stolitsa), Bulgaria

Multiprofile Hospital for Active Treatment "Knyaginya Klementina" - Sofia EAD

Sofia, Sofia (stolitsa), Bulgaria

Diagnostic Consultative Center Aleksandrovska

Sofia, Sofia (stolitsa), Bulgaria

University Multiprofile Hospital for Active Treatment Sveta Ekaterina EAD

Sofia, Sofia (stolitsa), Bulgaria

"Multiprofile Hospital for Active Treatment Puls" AD

Blagoevgrad, Bulgaria

Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD

Gabrovo, Bulgaria

Medical Center Hera - Kyustendil EOOD

Kyustendil, Bulgaria

MHAT - Heart and Brain

Pleven, Bulgaria

University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD

Plovdiv, Bulgaria

MHAT Hadzhi Dimitar

Sliven, Bulgaria

Аcibadem City Clinic University MHAT EOOD - Third Clinical Base

Sofia, Bulgaria

Medical Center Hera EOOD

Sofia, Bulgaria

Richmond Clinical Trials

Richmond, British Columbia, Canada

QEII Health Sciences Centre - Victoria General Site

Halifax, Nova Scotia, Canada

Health Sciences North Research Institute

Greater Sudbury, Ontario, Canada

ACV Clinic

Greater Sudbury, Ontario, Canada

CardioQuest Research Centre

Sarnia, Ontario, Canada

Corcare

Toronto, Ontario, Canada

Community Care Building

Winchester, Ontario, Canada

Winchester District Memorial Hospital

Winchester, Ontario, Canada

CIUSSS- saguenay-Lac-Saint-Jean

Chicoutimi, Quebec, Canada

CHU de Quebec - Université Laval - Hotel Dieu de Quebec

Québec, Quebec, Canada

Clinique de Médecins Spécialistes

Shebrooke, Quebec, Canada

Diex Recherche Sherbrooke Est

Sherbrooke, Quebec, Canada

Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur.

Terrebonne, Quebec, Canada

Diex Recherche Trois-Rivieres

Trois-Rivières, Quebec, Canada

Peking University First Hospital

Beijing, Beijing Municipality, China

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China

Hainan General Hospital

Haikou, Hainan, China

The Second Xiangya Hospital of Central South University

Changsha, Hunan, China

Jinan Central Hospital

Jinan, Shandong, China

Shanghai Tongji Hospital

Shanghai, Shanghai Municipality, China

Tianjin People' s Hospital

Tianjin, Tianjin Municipality, China

The First Affiliated Hospital of University of South China

Hengyang, China

Sdružené Zdravotnické Zařízení Krnov

Krnov, Moravian-Silesian Region, Czechia

Kardiologicka ambulance Brno s.r.o.

Brno-Královo Pole, Czechia

EFERTUS healthcare s.r.o.

Brno-Židenice, Czechia

Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia

EDUMED s.r.o.

Jaroměř, Czechia

VASOMED Clinic s.r.o.

Ostrava, Czechia

AGEL Stredomoravska nemocnicni, a.s., Nemocnice AGEL Prerov

Přerov, Czechia

Hôpital Arnaud de Villeneuve - CHU Montpellier

Montpellier, Hérault, France

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

Saint-Herblain, Loire-atlantique, France

Centre Hospitalier intercommunal de Toulon La Seyne sur Mer

Toulon, Provence-Alpes-Côte d'Azur Region, France

Chu Grenoble Alpes

Grenoble, France

Da Vinci Magánklinika

Pécs, Baranya, Hungary

CMed Rehabilitacios es Diagnosztikai Kozpont

Székesfehérvár, Fejér, Hungary

Ezüstfény Klinika Kft

Budapest, Hungary

Semmelweis Egyetem

Budapest, Hungary

Eszak-Pesti Centrumkorhaz-Honvedkorhaz

Budapest, Hungary

Jahn Ferenc Dél-pesti Hospital

Budapest, Hungary

New Medical Center Kft.

Sopron, Hungary

Kasugai Municipal Hospital

Kasugai, Aichi-ken, Japan

Nagoya Tokushukai General Hospital

Kasugai, Aichi-ken, Japan

Seikeikai New Tokyo Heart Clinic

Matsudo, Chiba, Japan

Toho University Sakura Medical Center

Sakura, Chiba, Japan

Teine Keijinkai Hospital

Sapporo, Hokkaido, Japan

Koga General Hospital

Koga, Ibaraki, Japan

Sagamihara Kyodo Hospital

Sagamihara, Kanagawa, Japan

Yokohama Municipal Citizen's Hospital

Yokohama, Kanagawa, Japan

National Hospital Organization Yokohama Medical Center

Yokohama, Kanagawa, Japan

National Hospital Organization Mie Chuo Medical Center

Tsu, Mie-ken, Japan

National Hospital Organization Sendai Medical Center

Sendai, Miyagi, Japan

Kishiwada Tokushukai Hospital

Kishiwada, Osaka, Japan

National Hospital Organization Saitama Hospital

Wako, Saitama, Japan

Tokyo Metropolitan Toshima Hospital

Itabashi-ku, Tokyo, Japan

Showa General Hospital

Kodaira-shi, Tokyo, Japan

National Hospital Organization Tokyo Medical Center

Meguro-Ku, Tokyo, Japan

NewHeart Watanabe Institute

Suginami, Tokyo, Japan

Sekino Hospital

Toshimaku, Tokyo, Japan

National Hospital Organization Iwakuni Clinical Center

Iwakuni, Yamaguchi, Japan

Nagasaki Harbor Medical Center

Nagasaki, Japan

NZOZ Centrum Medyczne KERmed

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu

Torun, Kuyavian-Pomeranian Voivodeship, Poland

SP ZOZ w Puławach

Puławy, Lublin Voivodeship, Poland

NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus

Sopot, Pomeranian Voivodeship, Poland

Kardio Brynow

Katowice, Silesian Voivodeship, Poland

Research and Cardiovascular Corp.

Ponce, Puerto Rico

CHUS - Hospital Clinico Universitario

Santiago de Compostela, A Coruña [LA Coruña], Spain

Parc de Salut Mar - Hospital del Mar

Barcelona, Barcelona [barcelona], Spain

Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [barcelona], Spain

Hospital de la Santa Creu i Sant Pau

Barcelona, Catalunya [cataluña], Spain

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Catalunya [cataluña], Spain

Hospital Universitario Puerta de Hierro

Majadahonda, Madrid, Spain

Hospital Universitario Ramón y Cajal

Madrid, Madrid, Comunidad de, Spain

Hospital Universitario La Paz

Madrid, Madrid, Comunidad de, Spain

Hospital Clinico de Valencia

Valencia, Valenciana, Comunitat, Spain

Hospital General Universitario de Valencia

Valencia, Spain

Hospital Universitari i Politecnic La Fe

Valencia, Spain

Ninewells Hospital and Medical School

Dundee, Dundee CITY, United Kingdom

St. George's Hospital

London, England, United Kingdom

Norfolk and Norwich University Hospitals NHS Foundation Trust

Norwich, Norfolk, United Kingdom

St Richard's Hospital

Chichester, WEST Sussex, United Kingdom

South Eastern Health and Social Care Trust

Belfast, United Kingdom

Wycombe General Hospital

High Wycombe, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

NCT06991257

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