RecruitingNCT06994169

Glofitamab in Real Life


Sponsor

The Lymphoma Academic Research Organisation

Enrollment

250 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

To date, more than 300 patients have been treated with Glofitamab in the Expanded Access Programme (EAP) in France. In this study, it is proposed to perform a retrospective analysis of some of these patients. The aim is to describe the efficacy and safety of Glofitamab in the largest reported real-world cohort, with an expected median follow-up of more than 9 months. Particular focus will be given to the relapsed or refractory chimeric antigen receptors-T (CAR-T) population to confirm the response rates (CRR: 35-39%) of Glofitamab in this population and to assess the optimal timing of therapy initiation \[8, 15\].


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting real-world data on how well glofitamab (a bispecific T-cell engaging antibody) works in clinical practice for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), outside of clinical trial conditions. **You may be eligible if...** - You are an adult patient with relapsed or refractory DLBCL - You were enrolled in the French glofitamab expanded access program before November 1, 2024 - You received the required obinutuzumab pre-treatment and at least one infusion of glofitamab - You have been informed about the study and do not object to your data being collected **You may NOT be eligible if...** - (There are no listed exclusion criteria for this observational study) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGlofitamab

Glofitamab received for DLBCL in Early Phase Access


Locations(30)

CH Victor Dupouy

Argenteuil, France

CH d'Avignon - Hôpital Henri Dufaut

Avignon, France

CH de la Côte Basque

Bayonne, France

CHRU Besançon - Hôpital Minjoz

Besançon, France

Hopital D'Instruction Des Armees Percy

Clamart, France

Hopital Henri Mondor

Créteil, France

CHU de Dijon - Hôpital le Bocage

Dijon, France

CH de Dunkerque

Dunkirk, France

CHU de Grenoble - Hôpital Albert Michallon

La Tronche, France

Hôpital de Libourne

Libourne, France

CHRU de LILLE - Claude Huriez

Lille, France

Hopital Saint Vincent-de-Paul

Lille, France

Centre Léon Bérard

Lyon, France

INSTITUT PAOLI CALMETTES - Service Hématologie

Marseille, France

Clinique du Pont de Chaume

Montauban, France

CH de Mulhouse Sud Alsace

Mulhouse, France

CHR d'Orléans

Orléans, France

Hopital Saint-Louis

Paris, France

Chu de Bordeaux - Hopital Haut-Leveque

Pessac, France

CHU Lyon Sud

Pierre-Bénite, France

CHU de Poitiers - Hôpital de La Milétrie

Poitiers, France

CH de Quimper Cornouaille

Quimper, France

CHU de Rennes - Hôpital de Pontchaillou

Rennes, France

Institut Curie - Site Saint-Cloud

Saint-Cloud, France

CHU de Strasbourg

Strasbourg, France

Institut Universitaire du Cancer de Toulouse - Oncopole

Toulouse, France

Chu Bretonneau

Tours, France

CHRU de Nancy - Hôpital de Brabois

Vandœuvre-lès-Nancy, France

Ch de Bretagne Atlantique

Vannes, France

Gustave Roussy Cancer Campus Grand Paris

Villejuif, France

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NCT06994169


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