RecruitingNot ApplicableNCT06995131

Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients


Sponsor

Uşak University

Enrollment

60 participants

Start Date

May 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.


Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study measures levels of two proteins — DEL-1 and IL-17 — in the fluid inside the eye (aqueous humor) of patients with cataracts, comparing people with type 2 diabetes to those without. The aim is to understand how diabetes-related inflammation may affect the eye. **You may be eligible if...** - You have been diagnosed with cataracts and are scheduled for cataract surgery - You have no other eye diseases besides cataracts - You have had type 2 diabetes for at least 5 years (for the diabetes group) **You may NOT be eligible if...** - You have had previous eye surgery - You have inflammatory eye diseases such as uveitis - You have autoimmune or systemic inflammatory diseases - You are currently taking steroid medications (local or systemic) - You have severe systemic illness such as advanced kidney failure or cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTDel 1

During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. DEL 1 will be analyzed by ELISA

DIAGNOSTIC_TESTIL 17

During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. IL 17 levels will be analyzed by ELISA


Locations(1)

Uşak Training and Research Hospital

Uşak, Uşak, Turkey (Türkiye)

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NCT06995131