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RecruitingNot ApplicableNCT06995131

Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients

Sponsor

Uşak University

Enrollment

60 participants

Start Date

May 1, 2025

Study Type

INTERVENTIONAL

Conditions

Diabetic Group (n=30)Non-diabetic Group

Summary

By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Inclusion Criteria3

  • Cataract diagnosed and surgery planned
  • Patients without any other ocular pathology other than cataract.
  • Type 2 DM for at least 5 years in the diabetic group

Exclusion Criteria5

  • Patients with previous intraocular surgery
  • Those with inflammatory eye diseases (e.g. uveitis)
  • Those with autoimmune diseases or systemic inflammatory diseases
  • Those receiving local or systemic steroid therapy
  • Those with severe systemic disease (e.g. advanced renal failure, malignancy)

Interventions

DIAGNOSTIC_TESTDel 1

During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. DEL 1 will be analyzed by ELISA

DIAGNOSTIC_TESTIL 17

During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. IL 17 levels will be analyzed by ELISA

Locations(1)

Uşak Training and Research Hospital

Uşak, Uşak, Turkey (Türkiye)

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NCT06995131