RecruitingPhase 1NCT06999187

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

A Phase 1a/1b, Multicenter, Open-label, Dose Escalation/Expansion, Multiple-dose Study to Evaluate the Safety and Activity of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas


Sponsor

Dren Bio

Enrollment

96 participants

Start Date

Jun 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A phase 1a/1b, multicenter, open-label, dose escalation/expansion, multiple-dose study to evaluate the safety and activity of DR-0202 in patients with locally advanced or metastatic, relapsed or refractory carcinomas


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new experimental cancer drug called DR-0202 in people with advanced or metastatic solid tumors — including breast, lung, cervical, prostate, pancreatic, head and neck, endometrial, ovarian, stomach, bladder, and other cancers — that have stopped responding to standard treatments. **You may be eligible if...** - You have one of the listed cancer types that has spread or cannot be surgically removed - You have already tried at least 2 prior treatment lines and no standard options remain - Your cancer shows measurable tumors on imaging scans - Your general health and organ function meet the study requirements - You are willing to provide tumor tissue samples **You may NOT be eligible if...** - You had major surgery within 28 days before starting the study - You have not waited long enough since your last cancer treatment - You have serious or uncontrolled infections, autoimmune disease, or other major health conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDR-0202

DR-0202 is a bispecific antibody


Locations(10)

Dren Investigational Site

Denver, Colorado, United States

Dren Investigational Site

Orlando, Florida, United States

Dren Investigational Site

Sarasota, Florida, United States

Dren Investigational Site

Huntersville, North Carolina, United States

Dren Investigational Site

Oklahoma City, Oklahoma, United States

Dren Investigational Site

Greenville, South Carolina, United States

Dren Investigational Site

Austin, Texas, United States

Dren Investigational Site

Dallas, Texas, United States

Dren Investigational Site

San Antonio, Texas, United States

Dren Investigational Site

Fairfax, Virginia, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06999187


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