Determining the Effect of Abiraterone on the Metabolism of Oxycodone in Men With Prostate Cancer (the ENABLE Study)

This study is examining whether abiraterone — a prostate cancer drug — affects how the body breaks down oxycodone, a common pain medication. Understanding this interaction could help doctors prescribe pain medications more safely to men on abiraterone. **You may be eligible if...** - You are a male 18 or older with prostate cancer - You are either currently taking abiraterone (1000 mg daily for at least 10 days) — or you are not taking it (as a comparison group) - Your BMI is between 18 and 30 kg/m² - You have adequate kidney and liver function **You may NOT be eligible if...** - You have used oxycodone recently (within 48 hours for short-acting, 96 hours for long-acting) - You have used other opioids in the past 14 days - You are taking other medications that interact with oxycodone - You have significant liver, kidney, or respiratory problems - You have a known allergy to oxycodone or a CYP enzyme variation that affects drug metabolism Talk to your doctor to see if this trial is right for you.