A Trial of HRS-4508 in Subjects With Locally Advanced or Metastatic Non-small Cell Lung Cancer

This study is testing a new drug called HRS-4508 for people with locally advanced or metastatic non-small cell lung cancer (NSCLC) that has stopped responding to standard treatments. **You may be eligible if...** - You are 18–80 years old with locally advanced or metastatic non-small cell lung cancer - Your cancer has progressed after (or you cannot tolerate) standard treatment - You are in good health (ECOG 0–1) - You have at least one measurable tumor outside the brain on imaging - You are expected to live at least 12 weeks and willing to follow the study schedule **You may NOT be eligible if...** - You have untreated or active cancer that has spread to the brain or spinal fluid - You have had a serious infection or major surgery in the past 4 weeks - You have another active cancer at the same time - You have severe nausea, vomiting, or digestive problems that would prevent taking oral medication Talk to your doctor to see if this trial is right for you.