RecruitingPhase 2NCT07003425

A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

A Long-term Extension Study to Evaluate the Safety and Efficacy of APG777 in Patients With Atopic Dermatitis Previously Treated With APG777


Sponsor

Apogee Therapeutics, Inc.

Enrollment

350 participants

Start Date

May 14, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a multicenter, double-blind, Long-Term Extension (LTE) study to evaluate the long-term safety and efficacy of APG777 in patients with moderate-to-severe AD who have completed treatment in an APG777 Parent Study (NCT06395948). The LTE study will consist of 3 periods: 1) Screening Visit will coincide with the last visit of the Maintenance Period in the Parent Study 2) Extended Treatment Period 3) Post-treatment Follow-up Period. This study will be conducted in participants with atopic dermatitis (AD) who completed the Treatment Period in a prior APG777 study and who, in the opinion of the Investigator, would benefit from long-term treatment with APG777.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called APG777, a drug called APG777, and others for people with atopic dermatitis. The study is currently recruiting participants at 50 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAPG777

APG777 subcutaneous injection

DRUGAPG777

APG777 subcutaneous injection every 12 weeks

DRUGAPG777

APG777 subcutaneous injection every 24 weeks


Locations(63)

Investigational Site

Fountain Valley, California, United States

Investigational Site

Los Angeles, California, United States

Investigational Site

Coral Gables, Florida, United States

Investigational Site

Jacksonville, Florida, United States

Investigational Site

Margate, Florida, United States

Investigational Site

Douglasville, Georgia, United States

Investigational Site

Skokie, Illinois, United States

Investigational Site

Bowling Green, Kentucky, United States

Investigational Site

Detroit, Michigan, United States

Investigational Site

Troy, Michigan, United States

Investigational Site

New York, New York, United States

Investigational Site

Wilmington, North Carolina, United States

Investigational Site

Boardman, Ohio, United States

Investigational Site

Mason, Ohio, United States

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Portland, Oregon, United States

Investigational Site

Pittsburgh, Pennsylvania, United States

Investigational Site

Charleston, South Carolina, United States

Investigational Site

Nashville, Tennessee, United States

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Dallas, Texas, United States

Investigational Site

Frisco, Texas, United States

Investigational Site

San Antonio, Texas, United States

Investigational Site

Mill Creek, Washington, United States

Investigational Site

Calgary, Alberta, Canada

Investigational Site

Calgary, Alberta, Canada

Investigational Site

Edmonton, Alberta, Canada

Investigational Site

Vancouver, British Columbia, Canada

Investigational Site

Fredericton, Brunswick, Canada

Investigational Site

Ajax, Ontario, Canada

Investigational Site

Markham, Ontario, Canada

Investigational Site

Mississauga, Ontario, Canada

Investigational Site

Ottawa, Ontario, Canada

Investigational Site

Peterborough, Ontario, Canada

Investigational Site

Toronto, Ontario, Canada

Investigational Site

Toronto, Ontario, Canada

Investigational Site

Toronto, Ontario, Canada

Investigational Site

Montreal, Quebec, Canada

Investigational Site

Québec, Quebec, Canada

Investigational Site

Prague, Czechia

Investigational Site

Prague, Czechia

Investigational Site

Heidelberg, Baden-Wurttemberg, Germany

Investigational Site

Tübingen, Baden-Wurttemberg, Germany

Investigational Site

Augsburg, Bavaria, Germany

Investigational Site

München, Bavaria, Germany

Investigational Site

Blankenfelde-Mahlow, Brandenburg, Germany

Investigational Site

Bad Bentheim, Lower Saxony, Germany

Investigational Site

Münster, North Rhine Westfalia, Germany

Investigational Site

Kiel, Schleswig-Holstein, Germany

Investigational Site

Hamburg, Germany

Investigational Site

Debrecen, Hajdú-Bihar, Hungary

Investigational Site

Wroclaw, Lower Silesian Voivodeship, Poland

Investigational Site

Wroclaw, Lower Silesian Voivodeship, Poland

Investigational Site

Lublin, Lublin Voivodeship, Poland

Investigational Site

Warsaw, Masovian Voivodeship, Poland

Investigational Site

Warsaw, Masovian Voivodeship, Poland

Investigational Site

Gdansk, Pomeranian Voivodeship, Poland

Investigational Site

Katowice, Silesian Voivodeship, Poland

Investigational Site

Sosnowiec, Silesian Voivodeship, Poland

Investigational Site

Szczecin, West Pomeranian Voivodeship, Poland

Investigational Site

Krakow, Woj. Małopolskie, Poland

Investigational Site

Lodz, Poland

Investigational Site

Santiago de Compostela, A Coruña, Spain

Investigational Site

Las Palmas de Gran Canaria, Canary Islands, Spain

Investigational Site

Madrid, Spain

View Full Details on ClinicalTrials.gov

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NCT07003425


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