Proving Utility of a New Field-cycling MRI Prototype in Acute Stroke Patients
University of Aberdeen
40 participants
Sep 16, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can show changes in the brain within the first day of a stroke due to a blocked blood vessel or bleeding in the brain. The main question it aims to answer is: • Can FCI identify brain tissue that might recover within the first few hours after a stroke begins? Participants will undergo a standard MRI scan and an FCI scan, as soon as possible after hospital admission. Participants who have had a blocked blood vessel will also provide a blood sample and will have a follow up visit at 30 days for repeat of both scans and providing another blood sample.
Eligibility
Inclusion Criteria4
- Acute stroke (<24 hours from symptom onset).
- NIHSS ≥4 and <25 with cortical involvement and/or large vessel occlusion on baseline imaging.
- Able to undergo 3T and FCI MRI <24h of onset.
- With or without thrombolysis.
Exclusion Criteria6
- Contraindications to MRI.
- Medically unstable.
- Unable to comprehend or comply with instructions regarding scanning
- Prior mRS of >3.
- Identified for thrombectomy.
- Non-stroke pathology or previous cortical infarct on CT scan > 1/3 of middle cerebral artery territory.
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Interventions
Baseline MRI scan
Baseline FCI scan
Day 30 3T MRI scan
Day 30 FCI scan
Thrombi from whole blood from ischaemic stroke patients will be formed and examined using bench top nuclear magnetic resonance (NMR) assays. At baseline and 30 days after stroke onset.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07004140