Multi-modal Adverse Events Prediction for Premature Coronary Heart Disease Trial: MAP-CHD Trial
China National Center for Cardiovascular Diseases
5,000 participants
Mar 31, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational cohort study is to establish a risk prediction model for adverse events in Chinese individuals under 45 years old with premature coronary artery disease. The main questions it aims to answer are: * What are the major risk factors for poor prognosis in Chinese patients with premature coronary artery disease? * What is the difference in the prognosis of patients with premature coronary heart disease with different phenotypes? Participants taking no mandatory intervention will be followed up for 2 year, with blood tests at 1 year and outpatient or telephone interviews at other timepoints.
Eligibility
Inclusion Criteria4
- Age 18-45 years;
- Clinically confirmed CAD with ≥50% luminal stenosis in at least one major coronary artery or significant branch, verified by coronary angiography;
- For acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) patients: clinical stability meeting discharge criteria post-treatment;
- Voluntary participation with signed informed consent.
Exclusion Criteria4
- Heart transplant recipients;
- Severe systemic comorbidities with life expectancy \<1 year;
- Previous enrollment in other drug/device clinical trials without completing the primary endpoint observation period;
- Inability to comply with follow-up (e.g., dementia, severe psychiatric disorders).
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07004452