Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults
Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Critically Ill Adults: A Cluster-Randomized, Cluster-Crossover Trial
Rush University Medical Center
880 participants
Jun 1, 2025
INTERVENTIONAL
Conditions
Summary
For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.
Eligibility
Inclusion Criteria4
- Admitted to intensive care unit (ICU)
- Age 18 years or older
- Requiring invasive mechanical ventilation for at least 24 hours
- Pass spontaneous breathing trial screen criteria
Exclusion Criteria7
- Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results
- Do not intubate (DNI) order
- Presence of tracheostomy
- Pregnancy
- Known prisoner
- Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures
- Enrolled in another clinical trial that impacts ventilator weaning or liberation
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Interventions
Spontaneous breathing trials will be conducted using the mode pressure support ventilation (PSV) with settings of a pressure support of 5 cmH2O and positive end expiratory pressure (PEEP) 5 cmH2O.
Spontaneous breathing trials will be conducted using the mode automatic tube compensation (ATC) with settings of 100% tube compensation and a positive end expiratory pressure (PEEP) of 5 cmH2O.
Locations(1)
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NCT07005505