RecruitingNot ApplicableNCT07011901

Precision Analytic Research Methods in OCD

Dissecting Neurocognitive Components of Compulsivity Using Computational Modeling and EEG

Sponsor

Icahn School of Medicine at Mount Sinai

Enrollment

100 participants

Start Date

Jul 9, 2025

Study Type

INTERVENTIONAL

Summary

Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This research study is investigating the underlying brain mechanisms of OCD (obsessive-compulsive disorder) using brain scans and other assessments — with the goal of improving future treatments. It involves both people with OCD and healthy volunteers for comparison. **You may be eligible if...** - You are 18–55 years old, right-handed, and English-speaking - You are able to provide consent to participate in research **You may NOT be eligible if...** - You have been diagnosed with OCD and also meet criteria for certain other psychiatric conditions - You are currently taking psychiatric medication or have recently received behavioral treatment for OCD - It would be physically unsafe for you to participate (e.g., metal implants incompatible with brain scanning) - Healthy control volunteers who meet criteria for significant psychiatric or neurological illness will also be excluded Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALExposure and Response Prevention

Exposure and response prevention (EX/RP) is the gold-standard behavioral treatment for OCD. It involves confronting the content of obsessions (distressing thoughts, images, or impulses) and resisting the urge to engage in compulsions (observable behaviors or mental acts that are repeated to reduce the anxiety/distress associated with compulsions).

Locations(1)

Icahn School of Medicine at Mount Sinai

New York, New York, United States

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NCT07011901