RecruitingNCT07013188

Characterising the Neuromuscular Function of Post Stroke Patients

Characterising the Neuromuscular Function of Stroke Patients During Recovery


Sponsor

University of Nottingham

Enrollment

16 participants

Start Date

Jun 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Strokes are a leading cause of death and disability in developed countries, with significant economic and social impacts. Defined by the WHO, strokes cause rapid and lasting disturbances in cerebral function. In the UK, strokes occur every five minutes, affecting 100,000 people annually and resulting in substantial physical impairments and financial costs. Although stroke-related deaths have decreased due to improved treatments and awareness, strokes remain a major cause of death and disability worldwide, especially in lower-income countries. Strokes typically cause unilateral deficits, leading to significant daily challenges and necessitating tailored rehabilitation strategies such as CIMT, FES, and VR Rehab. As the population ages, innovative neurorehabilitation approaches are essential to enhance functional recovery post-stroke. This pilot study aims to better understand the neuromuscular deficits caused by stroke to inform and improve future rehabilitation interventions, including the potential use of force accuracy training (FAT)


Eligibility

Min Age: 40 YearsMax Age: 85 Years

Inclusion Criteria4

  • • Aged between 40-85 years
  • Willing and able to give informed consent for participation in the study
  • Had a confirmed stroke within the last 5 years
  • Self-reports persisting post-stroke loss of unilateral limb function

Exclusion Criteria9

  • • Diagnosis of cognitive impairment/dementia
  • Current or recent (\<2y) malignancy
  • Severe respiratory disease (e.g., uncontrolled asthma, COPD, pulmonary hypertension)
  • Active cardiovascular disease: Uncontrolled hypertension (BP\>160/100mmHg); Recent (\<12mo) cardiac event; Heart failure (Class III/IV); Significant arrhythmia; Unstable angina
  • Metabolic disease: Untreated hyper/hypoparathyroidism; Cushing's disease
  • Significant musculoskeletal disorders (based on clinical opinion)
  • Dialysis patients
  • Recent steroid treatment within 6 months or hormone replacement therapy
  • Mobility dependant (wheelchair dependency)

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Interventions

OTHERNeuromuscular function

Assessing their neuromuscular abilities using some functional and electromyography assessments


Locations(1)

Royal Derby Hospital branch, School of Medicine, University of Nottingham

Derby, Derbyshire, United Kingdom

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NCT07013188


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