Medical Treatment Alone Versus Varicocelectomy Versus Varicocelectomy and Medical Treatment
Medical Treatment Alone Versus Varicocelectomy Versus Varicocelectomy and Medical Treatment in Management of Male Subfertility With Isolated Teratozoospermia: A Prospective Randomized Study
South Valley University
126 participants
Sep 1, 2024
INTERVENTIONAL
Summary
A varicocele is defined as an abnormal venous dilatation and/or tortuosity of the pampiniform plexus in the scrotum. Although varicoceles are almost always and more common on the left side, up to 50% of the men with varicocele, have bilateral varicoceles. Varicocele has a negative impact on spermatogenesis, testicular volume, Standard semen parameters, and fertilization, implantation, and embryo outcomes.
Eligibility
Inclusion Criteria2
- Sub-fertile men with clinically palpable varicoceles ( unilateral or bilateral ).
- Men with teratozoospermia.
Exclusion Criteria4
- Recurrent varicoceles.
- Significant medical diseases as: Hepatic insufficiency.
- Hypersensitivity to the drugs.
- Female factor of infertility.
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Interventions
to compare the efficacy of medical treatment (l-carnitine and antioxidants) versus surgical treatment (varicocelectomy) versus surgical treatment and medical treatment (varicocelectomy with adjuvant medications) on pregnancy rate on varicocele related subfertility patients with isolated teratozoospermia.
Locations(1)
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NCT07016867