RecruitingPhase 2NCT07018323

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Patients With Graves' Disease

Sponsor

Immunovant Sciences GmbH

Enrollment

210 participants

Start Date

Jun 19, 2025

Study Type

INTERVENTIONAL

Conditions

Graves Disease

Summary

This is a multi-center, global, randomized, double-blind, placebo-controlled Phase 2b study to assess the efficacy, safety, and tolerability of IMVT-1402 in adult participants with Graves' disease (GD) who are hyperthyroid despite antithyroid drug (ATD) treatment.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called IMVT-1402, a drug called IMVT-1402, and others for people with graves disease. The study is currently recruiting participants at 154 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIMVT-1402

Dose 1 for 26 weeks

DRUGIMVT-1402

Dose 2 for 26 weeks

DRUGPlacebo

For 26 weeks

Locations(158)

Site Number - 1015

Tucson, Arizona, United States

Site Number -1014

Concord, California, United States

Site Number - 1013

Aurora, Colorado, United States

Site Number - 1024

Doral, Florida, United States

Site Number - 1008

Hialeah, Florida, United States

Site Number - 1000

Miami, Florida, United States

Site Number - 1020

Columbus, Georgia, United States

Site Number - 1022

Topeka, Kansas, United States

Site Number - 1030

Louisville, Kentucky, United States

Site Number - 1033

Jefferson City, Missouri, United States

Site Number - 1004

Kansas City, Missouri, United States

Site Number - 1019

St Louis, Missouri, United States

Site Number - 1012

Reno, Nevada, United States

Site Number - 1032

Long Island City, New York, United States

Site Number - 1027

New Hyde Park, New York, United States

Site Number - 1009

New York, New York, United States

Site Number - 1018

Williamsville, New York, United States

Site Number - 1010

Chapel Hill, North Carolina, United States

Site Number - 1026

Hickory, North Carolina, United States

Site Number - 1001

Morehead City, North Carolina, United States

Site Number - 1034

Raleigh, North Carolina, United States

Site Number - 1007

Oklahoma City, Oklahoma, United States

Site Number - 1017

Memphis, Tennessee, United States

Site Number - 1029

Dallas, Texas, United States

Site Number - 1002

El Paso, Texas, United States

Site Number - 1003

Fort Worth, Texas, United States

Site Number - 1031

Houston, Texas, United States

Site Number - 1028

Houston, Texas, United States

Site Number -1023

Irving, Texas, United States

Site Number - 1021

Irving, Texas, United States

Site Number - 1025

McKinney, Texas, United States

Site Number - 1011

San Antonio, Texas, United States

Site Number - 1016

Norfolk, Virginia, United States

Site Number - 5105

Sydney, New South Wales, Australia

Site Number - 5103

Warrawong, New South Wales, Australia

Site Number - 5101

Brisbane, Queensland, Australia

Site Number - 5107

Douglas, Queensland, Australia

Site Number - 5100

Southport, Queensland, Australia

Site Number - 5102

Box Hill, Victoria, Australia

Site Number - 5104

Geelong, Victoria, Australia

Site Number - 5110

Parkville, Victoria, Australia

Site Number - 5108

Perth, Australia

Site Number - 5109

Saint Leonards, Australia

Site Number - 5511

Fortaleza, Ceará, Brazil

Site Number - 5513

Belo Horizonte, Minas Gerais, Brazil

Site Number - 5500

Campinas, São Paulo, Brazil

Site Number - 5505

Santo André, São Paulo, Brazil

Site Number - 5502

Brasília, Brazil

Site Number - 5503

Curitiba, Brazil

Site Number - 5504

Curitiba, Brazil

Site Number - 5501

Porto Alegre, Brazil

Site Number - 5512

Rio de Janeiro, Brazil

Site Number - 5506

São Paulo, Brazil

Site Number - 5508

São Paulo, Brazil

Site Number - 5510

São Paulo, Brazil

Site Number - 5507

São Paulo, Brazil

Site Number - 5509

São Paulo, Brazil

Site Number - 5610

Sofia, Sofia-Grad, Bulgaria

Site Number - 5613

Dobrich, Bulgaria

Site Number - 5606

Plovdiv, Bulgaria

Site Number - 5607

Plovdiv, Bulgaria

Site Number - 5601

Sliven, Bulgaria

Site Number - 5612

Smolyan, Bulgaria

Site Number - 5604

Sofia, Bulgaria

Site Number - 5609

Sofia, Bulgaria

Site Number - 5608

Sofia, Bulgaria

Site Number- 5605

Sofia, Bulgaria

Site Number - 5602

Varna, Bulgaria

Site Number - 5603

Varna, Bulgaria

Site Number - 5611

Varna, Bulgaria

Site Number - 5600

Yambol, Bulgaria

Site Number - 5700

Santiago, Chile

Site Number - 5701

Santiago, Chile

Site Number - 3203

Náchod, Czechia

Site Number - 3201

Prague, Czechia

Site Number - 3200

Prague, Czechia

Site Number - 3202

Prague, Czechia

Site Number - 8004

Imereti, Georgia

Site Number - 8003

Tbilisi, Georgia

Site Number - 8000

Tbilisi, Georgia

Site Number - 8002

Tbilisi, Georgia

Site Number - 8001

Tbilisi, Georgia

Site Number - 8005

Tbilisi, Georgia

Site Number - 3902

Athens, Greece

Site Number - 3900

Athens, Greece

Site Number - 3901

Athens, Greece

Site Number - 4202

Ramat Gan, Central District, Israel

Site Number - 4205

Haifa, Haifa District, Israel

Site Number - 4203

Haifa, Haifa District, Israel

Site Number - 4209

Nahariya, Northern District, Israel

Site Number - 4206

Tzfat, Northern District, Israel

Site Number - 4211

Beersheba, Southern District, Israel

Site Number - 4201

Jerusalem, Israel

Site Number - 4204

Jerusalem, Israel

Site Number - 4210

Kfar Saba, Israel

Site Number - 4200

Petah Tikva, Israel

Site Number - 4208

Rehovot, Israel

Site Number - 4207

Tel Aviv, Israel

Site Number - 6005

Rozzano, Milan, Italy

Site Number - 6013

Acquaviva delle Fonti, Italy

Site Number - 6004

Bergamo, Italy

Site Number - 6015

Cuneo, Italy

Site Number - 6011

Livorno, Italy

Site Number - 6003

Milan, Italy

Site Number - 6014

Naples, Italy

Site Number - 6006

Pavia, Italy

Site Number - 6001

Rome, Italy

Site Number - 6002

Udine, Italy

Site Number - 4010

Nagoya, Aichi-ken, Japan

Site Number - 4001

Kamogawa, Chiba, Japan

Site Number - 4011

Kitakyushu, Fukuoka, Japan

Site Number - 4004

Kurume, Fukuoka, Japan

Site Number - 4005

Minokamo, Gifu, Japan

Site Number - 4008

Maebashi, Gunma, Japan

Site Number - 4009

Yokohama, Kanagawa, Japan

Site Number - 4003

Nankoku, Kochi, Japan

Site Number - 4012

Shibuya City, Tokyo, Japan

Site Number - 4007

Kumamoto, Japan

Site Number - 4006

Kyoto, Japan

Site Number - 4002

Nagasaki, Japan

Site Number - 4600

Ogre, Latvia

Site Number - 4605

Riga, Latvia

Site Number - 4602

Riga, Latvia

Site Number - 4603

Riga, Latvia

Site Number - 4604

Sigulda, Latvia

Site Number - 4601

Ventspils, Latvia

Site Number - 2003

Rotterdam, South Holland, Netherlands

Site Number - 2200

Rotterdam, South Holland, Netherlands

Site Number - 2201

Rotterdam, South Holland, Netherlands

Site Number - 2202

Zwijndrecht, South Holland, Netherlands

Site Number - 3301

Auckland, New Zealand

Site Number - 3300

Wellington, New Zealand

Site Number - 3004

Bialystok, Podlaskie Voivodeship, Poland

Site Number - 3001

Szczecin, West Pomeranian Voivodeship, Poland

Site Number - 3002

Bydgoszcz, Poland

Site Number - 3010

Chorzów, Poland

Site Number - 3007

Kielce, Poland

Site Number - 3000

Lublin, Poland

Site Number - 3005

Olsztyn, Poland

Site Number - 3009

Opole, Poland

Site Number - 3006

Poznan, Poland

Site Number - 3008

Warsaw, Poland

Site Number - 3011

Warsaw, Poland

Site Nnumber - 3003

Wroclaw, Poland

Site Number - 4500

Daegu, South Korea

Site Number - 4503

Goyang, South Korea

Site Number - 4504

Guri-si, South Korea

Site Number - 4501

Seoul, South Korea

Site Number - 4508

Seoul, South Korea

Site Number - 4506

Seoul, South Korea

Site Number - 4505

Seoul, South Korea

Site Number - 4507

Seoul, South Korea

Site Number - 7009

Cornwell, United Kingdom

Site Number - 7006

London, United Kingdom

Site Number - 7001

London, United Kingdom

Site Number - 7003

Merthyr Tydfil, United Kingdom

Site Number - 7010

Salford, United Kingdom

Site Number - 7008

Surrey, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07018323

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